Conserved properties of dendritic trees in four cortical interneuron subtypes.

Scientific Reports
Yoshiyuki KubotaYasuo Kawaguchi

Abstract

Dendritic trees influence synaptic integration and neuronal excitability, yet appear to develop in rather arbitrary patterns. Using electron microscopy and serial reconstructions, we analyzed the dendritic trees of four morphologically distinct neocortical interneuron subtypes to reveal two underlying organizational principles common to all. First, cross-sectional areas at any given point within a dendrite were proportional to the summed length of all dendritic segments distal to that point. Consistent with this observation, total cross-sectional area was almost perfectly conserved at bifurcation points. Second, dendritic cross-sections became progressively more elliptical at more proximal, larger diameter, dendritic locations. Finally, computer simulations revealed that these conserved morphological features limit distance dependent filtering of somatic EPSPs and facilitate distribution of somatic depolarization into all dendritic compartments. Because these features were shared by all interneurons studied, they may represent common organizational principles underlying the otherwise diverse morphology of dendritic trees.

References

Sep 1, 1985·The Journal of Comparative Neurology·P K RoseS J Vanner
Oct 1, 1983·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·J HouchinA G Brown
Aug 15, 1997·Neural Computation·M L Hines, N T Carnevale
Sep 1, 1997·Cerebral Cortex·Y Kawaguchi, Y Kubota
Dec 22, 1999·Journal of Neurophysiology·D B Jaffe, N T Carnevale
Sep 12, 2002·Network : Computation in Neural Systems·Arjen van OoyenJaap van Pelt
Mar 4, 2003·Journal of Neurophysiology·Andreas T SchaeferArnd Roth
Aug 6, 2003·The Journal of Comparative Neurology·Akiko YamashitaAndreas Burkhalter
Nov 1, 1959·Experimental Neurology·W RALL
Mar 1, 1962·Biophysical Journal·W RALL
Mar 2, 1962·Annals of the New York Academy of Sciences·W RALL
Nov 19, 2003·Neuron·Jesse H GoldbergRafael Yuste
Mar 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fuyuki KarubeYasuo Kawaguchi
Aug 19, 2005·Cerebral Cortex·Yasuo KawaguchiYoshiyuki Kubota
Feb 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yoshiyuki KubotaYasuo Kawaguchi
Jun 15, 2007·Theoretical Biology & Medical Modelling·Hermann CuntzIdan Segev
Sep 22, 2007·Neural Computation·Bardia F Behabadi, Bartlett W Mel
May 21, 2010·PLoS Computational Biology·Ronald A J van Elburg, Arjen van Ooyen
Jul 2, 2010·The Journal of Comparative Neurology·Reza ZomorrodiIgor Timofeev

❮ Previous
Next ❯

Citations

Feb 1, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michele FerranteGiorgio A Ascoli
Jul 11, 2014·Cognitive Neurodynamics·Tadanobu Chuyo KamijoTakeshi Aihara
Jun 6, 2015·Cerebral Cortex·Naoki ShigematsuYasuo Kawaguchi
Mar 22, 2014·Current Opinion in Neurobiology·Yoshiyuki Kubota
Feb 8, 2018·Scientific Reports·Masanori Shimono, Naomichi Hatano
Apr 20, 2018·BMC Bioinformatics·Ajayrama KumaraswamyThomas Wachtler
May 29, 2018·Nature Neuroscience·Adam E Cohen, Samouil L Farhi
Mar 28, 2019·Molecular Neurobiology·Livia La BarberaParaskevi Krashia
Mar 22, 2018·Frontiers in Cellular Neuroscience·Hector ZuritaAlfonso Junior Apicella
Feb 6, 2019·Frontiers in Neurology·Anelia A Y KassiShyam Gajavelli
Feb 9, 2017·Cerebral Cortex·Crystal RockAlfonso Junior Apicella
Nov 30, 2018·Frontiers in Neural Circuits·Yoshiyuki KubotaYasuo Kawaguchi
Jan 30, 2020·Journal of Mathematical Neuroscience·Lu Yihe, Yulia Timofeeva
Aug 15, 2020·Frontiers in Neural Circuits·Alice BerteroAlfonso Junior Apicella
Jun 22, 2021·Frontiers in Neuroinformatics·Jonathan D Reed, Kim T Blackwell
Jul 28, 2021·ELife·Eugene A KatrukhaLukas C Kapitein

❮ Previous
Next ❯

Methods Mentioned

BETA
light
electron microscopy
light microscopy

Software Mentioned

Fiji
Visilog
TrakEM2
Neurolucida
NEURON
TurboReg
Reconstruct

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.