Conserved properties of HP1(Hsalpha)

Gene
Laura E NorwoodL L Wallrath

Abstract

Heterochromatin protein 1 Hsalpha (HP1(Hsalpha)) is one of three human proteins that share sequence similarity with Drosophila HP1. HP1 proteins are enriched at centric heterochromatin and play a role in chromatin packaging and gene regulation. In humans, HP1(Hsalpha) is down-regulated in highly invasive/metastatic breast cancer cells, compared to poorly invasive/non-metastatic breast cancer cells. To gain insight into this differential regulation, we have cloned the HP1(Hsalpha) gene and characterized its genomic region. HP1(Hsalpha) is located on human chromosome 12q13.13, 589 bp upstream of the divergently transcribed hnRNPA1 gene. Analysis of the promoter region revealed that differential regulation of HP1(Hsalpha) between the two types of breast cancer cells is lost upon mutation of an USF/c-myc transcription factor binding site located 172 bp upstream of the predicted HP1(Hsalpha) transcription start site. These findings provide insights into the down-regulation of HP1(Hsalpha) in highly invasive/metastatic breast cancer cells. To examine the functional properties of HP1(Hsalpha), experiments were performed using Drosophila melanogaster as a genetic system. When human HP1(Hsalpha) was expressed in transgenic Drosophila, s...Continue Reading

References

Jan 1, 1995·Annual Review of Genetics·K S Weiler, B T Wakimoto
Sep 11, 1999·Breast Cancer Research and Treatment·D A KirschmannM J Hendrix
Feb 5, 2000·Current Biology : CB·J F Smothers, S Henikoff
Apr 8, 2000·Current Opinion in Genetics & Development·J C Eissenberg, S C Elgin
Aug 25, 2000·Molecular and Cellular Biology·G WangP B Singh
Mar 22, 2001·Molecular and Cellular Biology·J F Smothers, S Henikoff
Jul 26, 2003·Oncogene·Ashraf DallolFarida Latif
Jan 28, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Alexander BrehmPeter B Becker

❮ Previous
Next ❯

Citations

Mar 1, 2006·Chromosoma·Kathryn L HuisingaSarah C R Elgin
Nov 26, 2008·Development Genes and Evolution·Matthew AnakaVett K Lloyd
Jul 2, 2009·Breast Cancer Research : BCR·Jason G LieberthalNaoko Tanese
Jan 17, 2007·Genome Biology·Gwen LomberkRaul Urrutia
Jun 19, 2007·Cell Structure and Function·Masaki KatoMasamitsu Yamaguchi
Jul 4, 2006·Genetics·Svetlana Minakhina, Ruth Steward
Feb 6, 2016·International Journal of Molecular Sciences·Bhairavi SrinageshwarJulien Rossignol
Jan 13, 2016·Cellular and Molecular Life Sciences : CMLS·Yan ZhouYonglun Luo
Jun 19, 2012·Clinical Epigenetics·Robert TellRichard V Benya
Oct 18, 2008·Mutation Research·George K DialynasLori L Wallrath
Feb 20, 2007·Mutation Research·Timothy J Moss, Lori L Wallrath
Aug 3, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Cui-Juan QianJian-Min Si
Mar 5, 2011·Molecular Carcinogenesis·Rune ThomsenAnders L Nielsen
Feb 2, 2011·The American Journal of Pathology·Robert TellRichard V Benya
Mar 23, 2013·Fly·Mia T Levine, Harmit S Malik
Apr 4, 2015·Trends in Genetics : TIG·Galit Lev MaorGil Ast
Feb 23, 2005·Current Biology : CB·Qiaoqiao WangGordon G Carmichael
Nov 22, 2011·Fungal Genetics and Biology : FG & B·Yazmid Reyes-DominguezJoseph Strauss
Jan 15, 2015·Cancer Biology & Therapy·Johan Vad-Nielsen, Anders Lade Nielsen
Jul 11, 2013·The Journal of Biological Chemistry·Rebecca L FaganCharles Brenner
Jan 15, 2014·The Journal of Biological Chemistry·Abdelhamid M AzzazMichael A Shogren-Knaak
May 2, 2006·The Journal of Biological Chemistry·Laura E NorwoodLori L Wallrath
Oct 13, 2006·Genome Génome / Conseil National De Recherches Canada·Andrew J Haigh, Vett K Lloyd
Oct 22, 2010·Epigenetics : Official Journal of the DNA Methylation Society·Artem K VelichkoSergey V Razin
Jun 25, 2004·Development·John R Danzer, Lori L Wallrath

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.