Conserved role of Sonic Hedgehog in tonotopic organization of the avian basilar papilla and mammalian cochlea

Proceedings of the National Academy of Sciences of the United States of America
Eun Jin SonJinwoong Bok

Abstract

Sound frequency discrimination begins at the organ of Corti in mammals and the basilar papilla in birds. Both of these hearing organs are tonotopically organized such that sensory hair cells at the basal (proximal) end respond to high frequency sound, whereas their counterparts at the apex (distal) respond to low frequencies. Sonic hedgehog (Shh) secreted by the developing notochord and floor plate is required for cochlear formation in both species. In mice, the apical region of the developing cochlea, closer to the ventral midline source of Shh, requires higher levels of Shh signaling than the basal cochlea farther away from the midline. Here, gain-of-function experiments using Shh-soaked beads in ovo or a mouse model expressing constitutively activated Smoothened (transducer of Shh signaling) show up-regulation of apical genes in the basal cochlea, even though these regionally expressed genes are not necessarily conserved between the two species. In chicken, these altered gene expression patterns precede morphological and physiological changes in sensory hair cells that are typically associated with tonotopy such as the total number of stereocilia per hair cell and gene expression of an inward rectifier potassium channel, IRK...Continue Reading

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Citations

Aug 1, 2015·Molecular Biology of the Cell·Peter-G Barr-Gillespie
Jan 21, 2016·Scientific Reports·Dean P CampbellAngelika Doetzlhofer
Sep 6, 2019·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Chao LiZhiyong Liu
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Aug 13, 2015·Wiley Interdisciplinary Reviews. Developmental Biology·Xiaowei Lu, Conor W Sipe
Aug 23, 2020·Proceedings of the National Academy of Sciences of the United States of America·Xiao-Jun Li, Angelika Doetzlhofer
May 3, 2020·Proceedings of the National Academy of Sciences of the United States of America·Woongsu HanChul Hoon Kim
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Nov 11, 2018·The Journal of Comparative Neurology·Austin R ShepardWei-Ming Yu

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