Considerable differences in vaccine immunogenicities and efficacies related to the diluent used for aluminum hydroxide adjuvant

Clinical and Vaccine Immunology : CVI
Lin LinBrad J Spellberg

Abstract

We are developing an anticandidal vaccine using the recombinant N terminus of Als3p (rAls3p-N). We report that although more rAls3p-N was bound by aluminum hydroxide diluted in saline than by aluminum hydroxide diluted in phosphate-buffered saline (PBS), its immunogenicity and efficacy were superior in PBS. Thus, protein binding, by itself, may not predict the efficacy of some vaccines with aluminum adjuvants.

References

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Citations

Dec 31, 2009·The Journal of Infectious Diseases·Beverlie BaquirBrad Spellberg
Aug 31, 2011·F1000 Medicine Reports·Brad Spellberg
Aug 27, 2010·Journal of Pharmaceutical Sciences·Tanya ClappLaToya Jones Braun
Jan 23, 2009·FEMS Immunology and Medical Microbiology·Lin LinBrad Spellberg
Aug 30, 2013·Clinical and Vaccine Immunology : CVI·Allan WatkinsonJeremy H Lakey
Jul 30, 2020·Journal of Fungi·Leandro B R Da SilvaJoshua D Nosanchuk
Nov 21, 2018·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Emma ShardlowChristopher Exley
Apr 19, 2019·Scientific Reports·Abdullah AlqarihiPriya Uppuluri
Feb 5, 2009·Journal of Virological Methods·Wan-Shoo CheongHans-Jürgen Netter

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