Consideration concerning similarities and differences between ANCA-associated vasculitis and IgG-4-related diseases: case series and review of literature

Immunologic Research
Hirotoshi KawashimaMasaki Hiraguri

Abstract

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and immunoglobulin G4-related diseases (IgG4-RD) are regarded as entirely different disease types with different etiological mechanisms. However, we experienced two cases that had clinical features of both AAV and IgG4-RD. The first case is an 81-year-old woman who showed periaortitis and retroperitoneal fibrosis and periarteritis with elevation of myeloperoxidase-anti-neutrophil cytoplasmic antibody and IgG4 levels. The second case is a 63-year-old woman who had dura mater, ear, nose, lung, and kidney involvement with serum negative for ANCA and elevated IgG4. Renal biopsy revealed tubulointerstitial nephritis involving IgG4+ plasma cells (IgG4+/IgG+ cell ratio of ≥ 40%). On the other hand, lung biopsy showed features of granulomatosis with polyangiitis (GPA). These two cases suggested that AAV and IgG4-RD might overlap. To investigate the similarities and differences between AAV and IgG4-RD, we retrospectively analyzed 13 cases of typical GPA, a subtype of AAV, and 13 cases of typical IgG4-RD at our hospital for comparison of clinical features and found some differences that can be useful in the differential diagnosis between the two diseases. Although AA...Continue Reading

References

Jan 1, 1993·Nephron·J C ter MaatenS J Hoorntje
Mar 12, 2002·Journal of Internal Medicine·A VaglioC Buzio
Sep 13, 2002·European Journal of Internal Medicine·E van BommelA van Vliet
Aug 26, 2003·The American Journal of Medicine·Elisabeth AslangulThomas Papo
Dec 21, 2005·Clinical Rheumatology·Clio P Mavragani, Michalis Voulgarelis
Jun 22, 2011·Modern Rheumatology·Shimpei KasagiShunichi Kumagai
Jan 6, 2012·Modern Rheumatology·Hisanori UmeharaHirotaka Ohara
Feb 10, 2012·The New England Journal of Medicine·John H StoneVikram Deshpande
Oct 4, 2012·Ocular Immunology and Inflammation·Yannis M PaulusDita Gratzinger
Oct 10, 2012·Arthritis and Rheumatism·J C JennetteR A Watts
Dec 27, 2015·The American Journal of Medicine·Krystallenia I AlexandrakiGregory A Kaltsas
Mar 12, 2017·Annals of the Rheumatic Diseases·Hisanori UmeharaTsutomu Chiba

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Citations

Jan 18, 2020·PloS One·Satoshi TsukudaKazuichi Okazaki
Jun 18, 2020·BMJ : British Medical Journal·Marco LanzillottaEmanuel Della-Torre
Jan 8, 2020·International Journal of Molecular Sciences·Hiroyuki MatsubayashiHiroyuki Ono
Feb 17, 2021·Clinical Rheumatology·Arzu Meltem DemirUmut Selda Bayrakci
Aug 25, 2020·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Yongjin JiChangqing Zhao
Sep 21, 2021·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Eduardo Martín-NaresSergio Paira

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Methods Mentioned

BETA
biopsy

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