Consideration of Epstein-Barr Virus-Encoded Noncoding RNAs EBER1 and EBER2 as a Functional Backup of Viral Oncoprotein Latent Membrane Protein 1

MBio
Kristina M Herbert, Genaro Pimienta

Abstract

The Epstein-Barr virus (EBV)-encoded noncoding RNAs EBER1 and EBER2 are highly abundant through all four latency stages of EBV infection (III-II-I-0) and have been associated with an oncogenic phenotype when expressed in cell lines cultured in vitro. In vivo, EBV-infected B cells derived from freshly isolated lymphocytes show that EBER1/2 deletion does not impair viral latency. Based on published quantitative proteomics data from BJAB cells expressing EBER1 and EBER2, we propose that the EBERs, through their activation of AKT in a B-cell-specific manner, are a functionally redundant backup of latent membrane protein 1 (LMP1)-an essential oncoprotein in EBV-associated malignancies, with a main role in AKT activation. Our proposed model may explain the lack of effect on viral latency establishment in EBER-minus EBV infection.

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Citations

Oct 27, 2018·Journal of Cellular Physiology·Mohsen MoghoofeiNiloofar Khodabandehlou
Oct 26, 2018·Journal of Virology·Vladimir MajerciakZhi-Ming Zheng
Nov 6, 2018·Medical Microbiology and Immunology·Huali YinRunliang Gan
Mar 10, 2017·Journal of Endocrinological Investigation·J F M AlmeidaL S Ward
Oct 27, 2020·Frontiers in Oncology·Polina ShindiapinaRobert A Baiocchi
Feb 26, 2021·Cancer Science·Kisato Nosaka, Masao Matsuoka
Aug 8, 2021·International Journal of Molecular Sciences·Valeria PietropaoloUgo Moens

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