PMID: 6976853Jan 1, 1981Paper

Considerations about the structure-activity relationships of 8-aminoquinoline antimalarial drugs

Bulletin of the World Health Organization
J D McChesney

Abstract

A discussion of the structure-activity relationships (SAR) of 8-aminoquinoline antimalarial drugs is presented. Consideration is given to the potential role of metabolic transformations in the in vivo activation of 8-aminoquinolines. It is emphasized that the mechanism of action of 8-aminoquinoline agents has not yet been established and thus any analysis of SAR must be speculative.

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