Abstract
The use of nanoadditives in food contact materials requires risk assessment to ensure consumers' safety. The evaluation of health risk is based on the combination of two elements: hazard and exposure. For nanomaterials (NM) used as additives in nanocomposites, the exposure is directly linked to the level of migration or release of the NM into the food. In principle, appropriate methods for experimental determination and theoretical estimation of migration are available but need diligent considerations to avoid erroneous conclusions from the measured data. We propose a comprehensive test scheme based on these methods, starting with characterization of the nanomaterial itself and when incorporated in the polymer. These data form the basis for making a decision whether migration of the NM can be excluded by migration theoretical considerations or if experimental migration testing and/or abrasion testing for mechanical release should be carried out. Guidance to and considerations for each of these steps and regarding the applicable methods are discussed. In conclusion, the results will provide a basis for risk assessment, either directly when exposure of consumers to the nanomaterials can be excluded or will be very low or, in the ...Continue Reading
References
May 18, 2005·Food Additives and Contaminants·T BegleyO Piringer
Oct 22, 2008·Analytical and Bioanalytical Chemistry·M BoubyF W Geyer
Oct 12, 2011·ACS Nano·Richard D GloverJames E Hutchison
Apr 10, 2012·Analytical Chemistry·Jani TuoriniemiMartin Hassellöv
Aug 12, 2014·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Johannes BottRoland Franz
Nov 15, 2014·ACS Applied Materials & Interfaces·Timothy V Duncan
Dec 9, 2014·ACS Applied Materials & Interfaces·Timothy V Duncan, Karthik Pillai
Jan 13, 2015·Analytical and Bioanalytical Chemistry·Björn Meermann
Jan 30, 2015·Analytical Chemistry·Francisco BarahonaJosefa Barrero-Moreno
Dec 17, 2015·Nanotoxicology·Aiga Mackevica, Steffen Foss Hansen
Apr 7, 2016·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Susana Addo NtimGregory O Noonan
Jul 5, 2016·Journal of Nanoparticle Research : an Interdisciplinary Forum for Nanoscale Science and Technology·Frank BabickVasile-Dan Hodoroaba
Aug 2, 2018·Journal of Food Science and Technology·Aristeidis S TsagkarisGeorgios P Danezis
Sep 29, 2018·Materials·Cornelia Vasile
Aug 23, 2019·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Susana Addo NtimGregory O Noonan
Oct 28, 2019·Critical Reviews in Food Science and Nutrition·Luciene de Oliveira MoraisIsabella Fernandes Delgado
Jul 1, 2014·Comprehensive Reviews in Food Science and Food Safety·Gregory O NoonanTimothy V Duncan
Jul 1, 2014·Comprehensive Reviews in Food Science and Food Safety·Gurmit SinghTimothy V Duncan