Considerations for Empiric Antimicrobial Therapy in Sepsis and Septic Shock in an Era of Antimicrobial Resistance.

The Journal of Infectious Diseases
Jeffrey R StrichHenry Masur

Abstract

Patients with sepsis present across a spectrum of infection sites and severity of illnesses requiring complex decision making at the bedside as to when prompt antibiotics are indicated and which regimen is warranted. Many hemodynamically stable patients with sepsis and low acuity of illness may benefit from further work up before initiating therapy, whereas patients with septic shock warrant emergent broad-spectrum antibiotics. The precise empiric regimen is determined by assessing patient and epidemiological risk factors, likely source of infection based on presenting signs and symptoms, and severity of illness. Hospitals should implement quality improvement measures to aid in the rapid and accurate diagnosis of septic patients and to ensure antibiotics are given to patients in an expedited fashion after antibiotic order.

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Citations

Jul 22, 2020·The Journal of Infectious Diseases·Edward J Septimus
Feb 13, 2021·Animals : an Open Access Journal From MDPI·Nicolás GalarceLisette Lapierre
Nov 15, 2020·Pharmacy : Journal of Pharmacy, Education and Practice·Nouf AbutheraaAlexander B Mullen
Mar 13, 2021·Journal of Clinical Pharmacy and Therapeutics·Bita ShahramiMojtaba Mojtahedzadeh
Apr 16, 2021·Critical Care Medicine·Chanu Rhee, Emily L Heil
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Jun 7, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Hakeam A HakeamSahar Althawadi

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