Considerations for Exercise Prescription in Patients With Bone Metastases: A Comprehensive Narrative Review

PM & R : the Journal of Injury, Function, and Rehabilitation
Gráinne SheillJuliette Hussey

Abstract

Metastatic disease is a frequent complication of advanced cancer, with bone representing one of the most common sites of metastatic occurrence. Patients with bone metastases receive long-term systemic treatments that have a significant attritional impact on muscle strength, fatigue, and physical functioning. Physical rehabilitation involving exercise and physical activity prescription has a considerable role in counteracting these changes; however, exercise is often perceived as a contraindication in the presence of bone metastases due to concerns about aggravating skeletal related events. This article examines the physical sequelae of bone metastases and outlines the factors for consideration with exercise prescription in metastatic bone disease, including bone health, pain levels, and oncologic treatment. This article includes a comprehensive review of the evidence from trials of exercise prescription in this population, including the efficacy and safety outcomes of exercise interventions. Exercise interventions for patients with bone metastases are associated with positive physical and self-reported outcomes. Studies reviewed reporting adverse events did not find a high fracture incidence with exercise in comparison with con...Continue Reading

References

Jul 1, 1992·British Journal of Clinical Pharmacology·S H Ralston
Jan 1, 1985·Clinical Orthopaedics and Related Research·R BuntingA Kliman
Dec 1, 1981·Acta Orthopaedica Scandinavica·M Fidler
Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisD Torgerson
Oct 7, 1998·Journal of Neurosurgery·Z L GokaslanR Sawaya
Jun 25, 1999·Research Quarterly for Exercise and Sport·C J JonesW C Beam
Dec 20, 1999·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·N ZojerM Pecherstorfer
Aug 24, 2001·Cancer·R W Bunting, B Shea
Aug 24, 2001·Cancer·J Santiago-Palma, R Payne
Nov 30, 2002·Journal of Pain and Symptom Management·Eugen B PetcuH Smith
May 2, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roanne J SegalGeorge A Wells
Apr 2, 2004·Australian Family Physician·Maria A Singh
May 29, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J Jaime CaroChristel Naujoks
Oct 19, 2004·Seminars in Oncology·Pierfranco Conte, Robert Coleman
Oct 30, 2004·Medicine and Science in Sports and Exercise·Wendy M KohrtUNKNOWN American College of Sports Medicine
Apr 2, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R E Coleman
Feb 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Teresa A RummansJean Hanson
May 24, 2006·Journal of Pain and Symptom Management·Line M OldervollStein Kaasa
Sep 14, 2006·European Journal of Cancer Care·C Stevinson, K R Fox
Sep 15, 2006·Clinical Oncology : a Journal of the Royal College of Radiologists·J S Y WuN Hagen
Mar 14, 2007·Journal of Pain and Symptom Management·James W CarsonJulie M Miller
Jun 26, 2008·Journal of Experimental & Clinical Cancer Research : CR·Mehmet SonmezSerdar Bedii Omay
Nov 11, 2008·Archives of Physical Medicine and Rehabilitation·Nancy K LathamJulie Chandler
Apr 9, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Carla M M PradoMichael B Sawyer
Jul 28, 2009·International Journal of Radiation Oncology, Biology, Physics·Edward ChowDeborah Bruner
Nov 11, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Sonya S LoweKerry S Courneya
Dec 2, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel A GalvãoRobert U Newton
Jan 7, 2010·Journal of Cancer Survivorship : Research and Practice·Rebecca M SpeckKathryn H Schmitz
Feb 10, 2010·Journal of the National Comprehensive Cancer Network : JNCCN·James MohlerPatrick C Walsh
Feb 16, 2010·Journal of Pain and Symptom Management·Jackson S Y WuNeil A Hagen
Mar 31, 2010·Clinical Orthopaedics and Related Research·Muhammad Umar Jawad, Sean P Scully
May 18, 2010·Expert Review of Anticancer Therapy·Stephen LutzPeter Hoskin
Jun 2, 2010·Physiotherapy Canada. Physiothérapie Canada·Rebekah BeatonSusan R Harris
Jun 10, 2010·American Journal of Physical Medicine & Rehabilitation·Andrea L ChevilleGail Gamble
Jun 19, 2010·Medicine and Science in Sports and Exercise·Kathryn H SchmitzUNKNOWN American College of Sports Medicine
Aug 4, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Barry J A LairdMarie T Fallon
Aug 17, 2010·The Lancet Oncology·Lee W JonesJeffrey Peppercorn
Feb 22, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Liam BourkeJohn M Saxton
Apr 9, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Liang ZengArjun Sahgal
Apr 22, 2011·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Zhonglai QianGuizhong Wu
Jun 28, 2011·Lancet·Russell K Portenoy

❮ Previous
Next ❯

Citations

Jul 4, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shuang YangPing Zhang
Oct 18, 2019·Journal of Anatomy·Michael A Berthaume, Anthony M J Bull
Jul 4, 2019·Wiener klinische Wochenschrift·Mohammad KeilaniRichard Crevenna
May 28, 2019·Integrative Biology : Quantitative Biosciences From Nano to Macro·Xueting MeiLidan You
Mar 30, 2021·Frontiers in Bioengineering and Biotechnology·Indira SigdelYuan Tang
Apr 25, 2021·Scientific Reports·Adrian Escriche-EscuderCristina Roldán-Jiménez
Jun 29, 2021·Current Physical Medicine and Rehabilitation Reports·Jasmine Y ZhengMitra D McLarney
Aug 2, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·André G GouveiaMauricio F Silva
Aug 7, 2021·Critical Reviews in Oncology/hematology·Sarah WellerKristin L Campbell
Nov 14, 2021·Current Osteoporosis Reports·Fabrizio PinAndrea Bonetto
Nov 13, 2021·Pediatric Blood & Cancer·Katrina M IngleySandra J Strauss

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Nader N MassarwehJanice N Cormier
Schweizerische Rundschau für Medizin Praxis = Revue suisse de médecine Praxis
M Jaeger
Journal of the Neurological Sciences
Roberta Balestrino, Pablo Martinez-Martin
© 2022 Meta ULC. All rights reserved