Considerations for the Optimization of Induced White Matter Injury Preclinical Models

Frontiers in Neurology
Abdullah Shafique AhmadSylvain Doré

Abstract

White matter (WM) injury in relation to acute neurologic conditions, especially stroke, has remained obscure until recently. Current advances in imaging technologies in the field of stroke have confirmed that WM injury plays an important role in the prognosis of stroke and suggest that WM protection is essential for functional recovery and post-stroke rehabilitation. However, due to the lack of a reproducible animal model of WM injury, the pathophysiology and mechanisms of this injury are not well studied. Moreover, producing selective WM injury in animals, especially in rodents, has proven to be challenging. Problems associated with inducing selective WM ischemic injury in the rodent derive from differences in the architecture of the brain, most particularly, the ratio of WM to gray matter in rodents compared to humans, the agents used to induce the injury, and the location of the injury. Aging, gender differences, and comorbidities further add to this complexity. This review provides a brief account of the techniques commonly used to induce general WM injury in animal models (stroke and non-stroke related) and highlights relevance, optimization issues, and translational potentials associated with this particular form of injury.

References

Dec 1, 1976·American Journal of Epidemiology·A LevitonP Yaney
Feb 1, 1976·Journal of the Neurological Sciences·F H GillesC S Kerr
Dec 1, 1992·British Journal of Pharmacology·M S MulliganP A Ward
Mar 1, 1992·Trends in Pharmacological Sciences·T SakuraiT Masaki
Jul 1, 1992·Stroke; a Journal of Cerebral Circulation·I ZivM Sokolovsky
Dec 1, 1990·The Journal of Experimental Medicine·H EhrenreichA S Fauci
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M W MacCumberS H Snyder
Jul 1, 1990·The Journal of Clinical Investigation·M E LeeT Quertermous
Jun 4, 1990·Brain Research·K A KadelF M Faraci
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P K StysP K Davis
Jan 26, 1990·Science·T YoshizawaI Kanazawa
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A GiaidJ M Polak
Sep 1, 1989·Acta Physiologica Scandinavica·K FuxeL F Agnati
Dec 1, 1988·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·M YanagisawaT Masaki
Jan 1, 1973·Journal of the Neurological Sciences·A Leviton, F H Gilles
Jun 1, 1973·Journal of Neurology, Neurosurgery, and Psychiatry·A Leviton, F H Gilles
Jul 1, 1984·Annals of Neurology·A Leviton, F H Gilles
Sep 1, 1982·Neuropathology and Applied Neurobiology·W F Blakemore
Jan 1, 1995·Annual Review of Physiology·S S Gross, M S Wolin
Apr 1, 1995·Trends in Pharmacological Sciences·A J HunterA J Cross
Feb 1, 1993·Stroke; a Journal of Cerebral Circulation·T KudoT Nishimura
Sep 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J SharkeyP A Kelly
Oct 1, 1995·Journal of Neurocytology·N D Jeffery, W F Blakemore
Jan 1, 1996·Biology of the Neonate·R A SheldonD M Ferriero
Sep 16, 1998·Current Opinion in Chemical Biology·B R Babu, O W Griffith

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Citations

Mar 24, 2016·Translational Stroke Research·Jukka Jolkkonen, Gert Kwakkel
Jan 9, 2017·Acta Neuropathologica·Clemens J Sommer
Apr 14, 2018·Stroke; a Journal of Cerebral Circulation·Robin L WebbSteven L Stice
Mar 25, 2017·Neurorehabilitation and Neural Repair·Matthew A EdwardsonAlexander W Dromerick
Jan 31, 2020·Neural Regeneration Research·Erin E Kaiser, Franklin D West
Nov 4, 2020·The Journal of Clinical Investigation·Yi XieXinfeng Liu
Apr 3, 2021·Frontiers in Cell and Developmental Biology·Samantha E Spellicy, David C Hess

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Methods Mentioned

BETA
imaging techniques
transmission electron microscopy

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