PMID: 5257130Jun 1, 1969Paper

Considerations of the concept of structural homology as applied to bovine carboxypeptidases A and B

Proceedings of the National Academy of Sciences of the United States of America
R A BradshawK A WALSH

Abstract

An argument is presented in favor of the hypothesis that, bovine carboxypeptidases A and B fit by and large, the concept of homology on the levels of both amino acid sequence and three-dimensional structure. Two peptide sequences from carboxypeptidases A and B, comprising 46 amino acid residues, display structural homology to the extent of 51 per cent. One of the two peptides contains two of the amino acid residues which have been identified by X-ray crystallography as zinc ligands in carboxypeptidase A. The same residues are conserved in carboxypeptidase B in a loop of comparable dimensions. The other homologous pair of amino acid sequences appears to occur in different regions of the two enzymes which include in carboxypeptidase B the cysteinyl residue proposed to function as the third zinc ligand but not the amino acid residue believed to be the analogous ligand in carboxypeptidase A. The uncertainties of this prediction are considered in the light of existing chemical and structural evidence.

References

Dec 29, 1967·Science·H NeurathW P Winter
Feb 1, 1968·Archives of Biochemistry and Biophysics·M ElzingaC Y Lai
Feb 1, 1968·Archives of Biochemistry and Biophysics·M Elzinga, C H Hirs
Aug 1, 1965·Biochemistry·E WintersbergerB L Wallee
Sep 11, 1965·Nature·B S HartleyL B Smillie
Oct 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·K A WALSH, H NEURATH

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Citations

Aug 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·R A BradshawH Neurath
Jul 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·S M Aloj, H Edelhoch
Jun 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·G R ReeckH Neurath
May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·K TitaniH Neurath
Apr 27, 1971·Biochimica Et Biophysica Acta·J R Uren
Mar 14, 1972·Journal of Molecular Biology·A D McLachlan
May 5, 1976·Journal of Molecular Biology·M F Schmid, J R Herriott
Mar 25, 1974·Journal of Molecular Biology·M F Schmid, J R Herriott
Jan 1, 1970·Biochemical and Biophysical Research Communications·S TakahashiM Binder
Jul 25, 1972·Biochemical and Biophysical Research Communications·M M Werber, M Sokolovsky
Aug 9, 1977·Biochemistry·G M AlterB L Vallee
Mar 1, 1971·Journal of the American Oil Chemists' Society·L Butler
Jan 1, 1971·European Journal of Biochemistry·O A Roholt, D Pressman

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