Considerations on joint and articular cartilage mechanics

Biomechanics and Modeling in Mechanobiology
W Herzog, S Federico

Abstract

When studying joint degeneration leading to osteoarthritis (OA), it seems imperative that local joint tissue loading is known during normal everyday movement and that the adaptive/degenerative effects of this loading are quantified systematically. Philosophically, we believe the best way to approach this problem is by studying joint degeneration and osteoarthritis in long-term experimental models and by representing diarthrodial joints and the associated tissues with accurate, geometric and structural, theoretical models. Here, we present selected examples of our work representing this approach. Experimentally, we demonstrate that the local loading of joints changes continuously in experimental models of OA, not only because of the changing external and internal loading, but also because of the continuous alterations in joint contact geometry and tissue mechanical properties. Furthermore, we show that single bouts of joint loading affect gene expression, and that gene expression, as well as subsequent joint degeneration is site-specific. In fact, opposing articular surfaces that are exposed to the same loading may degenerate at completely different rates. Finally, we propose a series of theoretical models of articular cartilage...Continue Reading

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Citations

Mar 1, 2006·Biomechanics and Modeling in Mechanobiology·S-K HanW Herzog
Nov 4, 2006·Biomechanics and Modeling in Mechanobiology·Gerard A Ateshian
Jul 10, 2007·Biomechanics and Modeling in Mechanobiology·Salvatore Federico, Walter Herzog
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May 18, 2010·Journal of Feline Medicine and Surgery·Natalie GabrielAnne Vaughan-Thomas
Dec 5, 2006·The Orthopedic Clinics of North America·E Anne Ouellette, Anna-Lena Makowski
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May 12, 2009·Osteoarthritis and Cartilage·A Rehan YoussefW Herzog
Oct 19, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Jonathan T KaplanDavid M Pierce
Oct 23, 2009·The American Journal of Sports Medicine·Wouter SchuurmanJos Malda
Nov 17, 2016·Frontiers in Bioengineering and Biotechnology·Ivan Argatov, Gennady Mishuris
Oct 5, 2021·Tissue Engineering. Part B, Reviews·Sarah M Cooper, Roshni Suresh Rainbow

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