Abstract
The consideration of the collective significance of the shared characteristics and overlaps in the clinical expression and pharmacological responses of the major mental disorders (namely, schizophrenia, bipolar disorders, obsessive compulsive disorder, anxieties/phobias, borderline syndrome and possibly others) supports the following: (1) These disorders have a common, initial neurodevelopmental origin. (2) They occur probabilistically on some of "at-risk" individuals whose pre-existing, extreme, temperamental/structural variance confers vulnerability for such occurrence. (3) Lastly, each of these syndromes can be considered as a clinical expression of oscillations (i.e., a switch to a pathologically ordered phase) of the overall, common operating mode of brain function. This mode based on a particular-for-our-brain, emergent quality of complexity, normally ensures the synchrony, coordination, subtlety and robust flexibility in the expression of the components of each of the various higher faculties of the brain, namely, the faculty of: (1) mood modulation; (2) coordination of feelings, thoughts and the responses to the external world; and (3) keeping constrain and limited but appropriate input of primitive drives. The conclusi...Continue Reading
References
Sep 1, 1992·Medical Hypotheses·N Pediaditakis
Jan 1, 1991·Progress in Neurobiology·C C King
Oct 1, 1987·The American Journal of Psychiatry·N C Andreasen
Jan 1, 1994·Acta Psychiatrica Scandinavica. Supplementum·N C AndreasenM Flaum
Jan 1, 1994·Psychopathology·V Arolt, H Dilling
Dec 1, 1993·Archives of General Psychiatry·C R CloningerT R Przybeck
Jan 1, 1994·The American Journal of Psychiatry·A BreierW T Carpenter
Nov 1, 1993·Journal of the American Academy of Child and Adolescent Psychiatry·D M FergussonM T Lynskey
Feb 1, 1993·The American Journal of Psychiatry·M A TaylorC R Cloninger
Jan 1, 1996·Archives of General Psychiatry·N Pediadiatakis
Jan 1, 1996·Schizophrenia Bulletin·A R Yung, P D McGorry
Aug 5, 1998·Medical Hypotheses·N Pediaditakis
Sep 25, 1999·The Medical Journal of Australia·C WijeratneR W Lyndon
Dec 30, 1999·The Journal of ECT·C Wijeratne, S Shome
Jun 29, 2001·Archives of General Psychiatry·R F AsarnowK S Kendler
Oct 31, 2001·Journal of Psychiatric Research·C HenryL J Siever
Feb 2, 2002·The American Journal of Psychiatry·Andrew E SkodolJohn M Oldham
Mar 1, 2002·Journal of Affective Disorders·Marlene P FreemanSusan L McElroy
Mar 27, 2002·Current Psychiatry Reports·Alysa E Doyle, Stephen V Faraone
Jun 14, 2002·Biological Psychiatry·Andrew E SkodolLarry J Siever
Jan 28, 2003·European Psychiatry : the Journal of the Association of European Psychiatrists·Andrei SzökeMarion Leboyer
Jul 2, 2003·Journal of Clinical Psychopharmacology·Lakshmi N Yatham
Oct 8, 2003·Clinical Psychology Review·Jo Anne Neal, Robert J Edelmann
Dec 23, 2003·Bipolar Disorders·Lakshmi N YathamRaymond W Lam
Jan 1, 2004·Bipolar Disorders·Roger McIntyre, Martin Katzman
Aug 5, 2004·The Journal of Clinical Psychiatry·Bridget F GrantRoger P Pickering
Dec 31, 2004·The American Journal of Psychiatry·Matcheri S KeshavanNina R Schooler
Mar 26, 2008·Archives of Internal Medicine·Harvey J MurffWilliam J Blot
Jan 8, 2010·Schizophrenia Research·D L FogelsonK H Nuechterlein
Jan 5, 2011·Journal of Affective Disorders·Xenia GondaHagop S Akiskal