Consistency in recognizing microinvasion in breast carcinomas is improved by immunohistochemistry for myoepithelial markers

Virchows Archiv : an International Journal of Pathology
Gábor CserniS Bianchi

Abstract

Microinvasion is the smallest morphologically identifiable stage of invasion. Its presence and distinction from in situ carcinoma may have therapeutic implications, and clinical staging also requires the recognition of this phenomenon. Microinvasion is established on the basis of several morphological criteria, which may be difficult and not perfectly reproducible among pathologists. The aim of this study was to assess the consistency of diagnosing microinvasion in the breast on traditional haematoxylin and eosin (HE) stained slides and to evaluate whether immunohistochemistry (IHC) for myoepithelial markers could improve this. Digital images were generated from representative areas of 50 cases stained with HE and IHC for myoepithelial markers. Cases were specifically selected from the spectrum of in situ to microinvasive cancers. Twenty-eight dedicated breast pathologists assessed these cases at different magnifications through a web-based platform in two rounds: first HE only and after a washout period by both HE and IHC. Consistency in the recognition of microinvasion significantly improved with the use of IHC. Concordance rates increased from 0.85 to 0.96, kappa from 0.5 to 0.85, the number of cases with 100% agreement rose...Continue Reading

References

Apr 6, 1999·Virchows Archiv : an International Journal of Pathology·S DamianiV Eusebi
Jan 31, 2006·Journal of Clinical Pathology·I O EllisR Winder
Nov 21, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N PerryL von Karsa
May 22, 2008·Pathology Oncology Research : POR·Simonetta Bianchi, Vania Vezzosi
Oct 22, 2008·The American Journal of Surgical Pathology·Justin B HilsonLaura C Collins
May 14, 2010·The American Journal of Surgical Pathology·Justin B HilsonLaura C Collins
Feb 22, 2012·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Gábor Cserni
Nov 19, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H GojonA Valachis
Apr 20, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Matthew G HannaAnupma Nayak
Sep 4, 2015·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Bence KőváriGábor Cserni

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