Dec 21, 2011

Consistency of genome-wide associations across major ancestral groups

Human Genetics
E E NtzaniJohn P A Ioannidis

Abstract

It is not well known whether genetic markers identified through genome-wide association studies (GWAS) confer similar or different risks across people of different ancestry. We screened a regularly updated catalog of all published GWAS curated at the NHGRI website for GWAS-identified associations that had reached genome-wide significance (p ≤ 5 × 10(-8)) in at least one major ancestry group (European, Asian, African) and for which replication data were available for comparison in at least two different major ancestry groups. These groups were compared for the correlation between and differences in risk allele frequencies and genetic effects' estimates. Data on 108 eligible GWAS-identified associations with a total of 900 datasets (European, n = 624; Asian, n = 217; African, n = 60) were analyzed. Risk-allele frequencies were modestly correlated between ancestry groups, with >10% absolute differences in 75-89% of the three pairwise comparisons of ancestry groups. Genetic effect (odds ratio) point estimates between ancestry groups correlated modestly (pairwise comparisons' correlation coefficients: 0.20-0.33) and point estimates of risks were opposite in direction or differed more than twofold in 57%, 79%, and 89% of the European...Continue Reading

  • References49
  • Citations33

References

  • References49
  • Citations33

Citations

Mentioned in this Paper

Genome-Wide Association Study
African Continental Ancestry Group
Genetic Markers
European Continental Ancestry Group
Genomics
Genetic Equilibrium
Korean Race
Alleles
Genetic Predisposition to Disease
Single Nucleotide Polymorphism

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