Consistent LEF-1 and MYB Immunohistochemical Expression in Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma: A Potential Diagnostic Pitfall

Head and Neck Pathology
Akeesha A ShahJustin A Bishop

Abstract

Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC) is a distinct, newly-described sinonasal tract neoplasm characterized by a salivary gland tumor-like appearance with myoepithelial and ductal cells, frequent surface squamous dysplasia, and relatively indolent behavior. When considering a diagnosis of HMSC, aggressive high-grade salivary gland carcinomas, particularly those with a basaloid morphology such as basal cell adenocarcinoma and adenoid cystic carcinoma, enter the differential diagnosis. The full morphologic and immunophenotypic profile of HMSC continues to be unraveled. In this series of ten cases, we demonstrate that this tumor has consistent, strong immunohistochemical expression of LEF-1 yet lacks nuclear expression of β-catenin, and also has consistent yet variable expression of MYB protein. While LEF-1 expression may be a useful diagnostic adjunct, it can also be a pitfall, as other salivary tumors such as basal cell adenocarcinoma have been previously shown to express LEF-1. Additionally, MYB protein expression is not a discriminatory marker when trying to separate HMSC from adenoid cystic carcinoma.

References

Dec 5, 2006·Oncogene·L ArceM L Waterman
Jul 22, 2009·Developmental Cell·Bryan T MacDonaldXi He
Oct 21, 2009·Proceedings of the National Academy of Sciences of the United States of America·Marta PerssonGöran Stenman
Feb 18, 2011·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Akihiko KawaharaMasayoshi Kage
May 17, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Louis B BrillHenry F Frierson
Oct 26, 2012·The American Journal of Surgical Pathology·Justin A BishopWilliam H Westra
Dec 17, 2014·Human Pathology·Elizabeth A BilodeauRaja R Seethala
Dec 4, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yoshitsugu MitaniAdel El-Naggar
Jun 4, 2016·The American Journal of Surgical Pathology·Vickie Y JoJeffrey F Krane
Sep 13, 2016·Oncogene·T ZhanM Boutros
Jan 7, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Raja R Seethala
Oct 4, 2017·Diagnostic Cytopathology·Alessandra C SchmittMomin T Siddiqui

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Citations

Jun 11, 2020·The American Journal of Surgical Pathology·Lisa M RooperJustin A Bishop

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