PMID: 9419351Feb 21, 1998Paper

Consistent loss of functional transforming growth factor beta receptor expression in murine plasmacytomas

Proceedings of the National Academy of Sciences of the United States of America
Stephanie AmorosoJohn J Letterio

Abstract

Murine plasmacytomas are tumors of Ig-secreting plasma cells that can be induced in genetically susceptible BALB/c mice. The deregulation of the c-myc protooncogene is a critical oncogenic event in the development of plasmacytomas (PCTs) although it is not sufficient for their malignant transformation. We have demonstrated that PCTs produce active transforming growth factor beta (TGF-beta) in vitro. Because TGF-beta is a potent negative regulator of the proliferation and differentiation of B lymphocytes, we examined its role in plasmacytomagenesis by comparing responsiveness to TGF-beta of nonneoplastic plasma cells and PCTs. The nontransformed plasma cells that accumulate in interleukin 6 transgenic mice undergo accelerated apoptosis upon treatment with TGF-beta, but the 15 PCTs studied, including primary and transplanted tumors as well as established cell lines, were refractory to TGF-beta-mediated growth inhibition and apoptosis. Although PCTs lack functional TGF-beta receptors as demonstrated by chemical crosslinking to radiolabeled TGF-beta1, they nonetheless contain mRNA and protein for both type I and II TGF-beta receptors, suggesting a potential defect in receptor trafficking or processing. The results clearly show the ...Continue Reading

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Citations

Aug 24, 1999·Medical Oncology·W R FriedenbergJ K Burmester
Sep 5, 2006·Cancer Metastasis Reviews·Sonia B Jakowlew
May 22, 2002·The Journal of Experimental Medicine·Tania FernandezJohn J Letterio
Jul 27, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Iris IsufiAmit Verma
Feb 18, 2006·Blood·Mei Dong, Gerard C Blobe
Sep 5, 2012·Journal of Translational Medicine·Lenka KubiczkovaSabina Sevcikova
Jul 9, 2003·Immunological Reviews·Michael Potter
Oct 5, 2001·Nature Genetics·R DerynckA Balmain
Jun 24, 2009·International Journal of Cancer. Journal International Du Cancer·Fabrício de CarvalhoAndré L Vettore
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Linda B BaughnSelina Chen-Kiang
Dec 2, 2000·Seminars in Cancer Biology·J R BerensonR A Vescio

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