Consolidation of proteomics data in the Cancer Proteomics database

Proteomics
Magnus Ø ArntzenBernd Thiede

Abstract

Cancer is a class of diseases characterized by abnormal cell growth and one of the major reasons for human deaths. Proteins are involved in the molecular mechanisms leading to cancer, furthermore they are affected by anti-cancer drugs, and protein biomarkers can be used to diagnose certain cancer types. Therefore, it is important to explore the proteomics background of cancer. In this report, we developed the Cancer Proteomics database to re-interrogate published proteome studies investigating cancer. The database is divided in three sections related to cancer processes, cancer types, and anti-cancer drugs. Currently, the Cancer Proteomics database contains 9778 entries of 4118 proteins extracted from 143 scientific articles covering all three sections: cell death (cancer process), prostate cancer (cancer type) and platinum-based anti-cancer drugs including carboplatin, cisplatin, and oxaliplatin (anti-cancer drugs). The detailed information extracted from the literature includes basic information about the articles (e.g., PubMed ID, authors, journal name, publication year), information about the samples (type, study/reference, prognosis factor), and the proteomics workflow (Subcellular fractionation, protein, and peptide separ...Continue Reading

References

Mar 25, 2005·Nature Reviews. Drug Discovery·Dong Wang, Stephen J Lippard
Jul 13, 2007·Nature Reviews. Cancer·Lloyd Kelland
Apr 3, 2008·Current Opinion in Urology·Robert E Mitchell, Sam S Chang
Aug 27, 2010·Molecular Systems Biology·Kei-Hoi CheungMark B Gerstein
Oct 20, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·S JoshiA Sharma
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Oct 4, 2011·Journal of Proteomics·Xin-Hui LiZhi-Qiang Xiao
Nov 10, 2011·Molecular & Cellular Proteomics : MCP·Magnus Ø Arntzen, Bernd Thiede
Mar 17, 2012·Mass Spectrometry Reviews·Hwee Tong TanMaxey C M Chung
Mar 31, 2012·Science Translational Medicine·John R PrensnerArul M Chinnaiyan
Dec 26, 2012·Clinical Biochemistry·Elisa PinEmanuel F Petricoin
Jan 23, 2013·The Cancer Journal·Robert R ZielinskiKim N Chi
Mar 30, 2013·Journal of Proteome Research·Magnus Ø ArntzenBernd Thiede

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Citations

Apr 25, 2018·Database : the Journal of Biological Databases and Curation·Qingmin YangLu Xie
Dec 19, 2019·Frontiers in Bioengineering and Biotechnology·Lei ChenYu-Dong Cai

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