Consolidation responses of delipidized articular cartilage

Clinical Biomechanics
A O OloyedeB A Hills

Abstract

To determine the role of articular cartilage lipids in its load-bearing function. Normal and delipidised, bovine articular cartilage specimens were statically loaded and both the hydrostatic excess pore pressure and creep strain were measured. From this the compression stiffness of the skeletal structures of both types of matrices was determined. It has been hypothesized that surfactant injection could relief osteoarthritis, but there is no study in the literature relating to the influence of lipids, the main ingredients of such products, on cartilage load-carriage. Articular cartilage specimens were obtained from the patellar grooves of 2-3 year old bovine animals. When required specimen delipidization was carried out using chloroform/methanol rinsing. Both normal and delipidised samples were loaded in the consolidometer and the hydrostatic excess pore pressure and strain were measured. The transient patterns of the hydrostatic excess pore pressure were similar for both types of tissue, with a relatively insignificant increase of 2% in the maximum hydrostatic excess pore pressure of the delipidized samples relative to the normal intact specimens. The maximum creep strain of the delipidised specimens decreased by 10% on average...Continue Reading

References

Sep 1, 1975·Arthritis and Rheumatism·W M BonnerM Bryant
Aug 1, 1984·Annals of the Rheumatic Diseases·B A Hills, B D Butler
Aug 24, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A V SarmaM LaBerge
Mar 1, 1965·Annals of the Rheumatic Diseases·D H COLLINSG MEACHIM
Mar 1, 1965·Annals of the Rheumatic Diseases·F N GHADIALLYD H COLLINS
Nov 1, 1991·Clinical Biomechanics·A O Oloyede, N D Broom
May 1, 1994·Clinical Biomechanics·A O Oloyede, N D Broom

Citations

Feb 14, 2013·Journal of Materials Science. Materials in Medicine·Kehinde Q YusufA O Oloyede
Aug 28, 2007·Journal of Orthopaedic Surgery and Research·Yi ChenA O Oloyede
Nov 14, 2014·Cell Biochemistry and Biophysics·Zenon PawlakWojciech Hagner
Jan 3, 2015·Biointerphases·Zenon PawlakWojciech Hagner
Dec 18, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Sarit SivanYechezkel Barenholz

Related Concepts

Adaptation, Physiological
Structure of Articular Cartilage
Bos indicus
Elasticity
Extracellular Matrix
Lipids
Stress, Mechanical

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