Conspecific odor exposure predominantly activates non-kisspeptin cells in the medial nucleus of the amygdala

Neuroscience Letters
Leandro Bueno LimaRenata Frazao

Abstract

A small neuronal subpopulation in the medial nucleus of the amygdala (MeA), expressing the Kiss1 gene, is now considered an important mediator that integrates socio-sexual behavior and odor information in order to modulate the Hypothalamic-Pituitary-Gonadal (HPG) axis. Previous studies demonstrated that exogenous kisspeptin administration or selective activation of Kiss1-expressing neurons in the MeA modulates the onset of puberty, LH secretion and sexual behavior. These functions are supported by the known MeA neuronal connections. In the MeA, as well as in the hypothalamus, Kiss1 mRNA expression mostly depends on sex steroids levels. However, the percentage of Kiss1-expressing cells that co-express estrogen receptor α (ERα) in the MeA is currently unknown. Additionally, whether MeA kisspeptin neurons show Fos expression due to pheromone exposure is still undisclosed. In the present study, we used adult male and female mice that express a reporter protein under the Kiss1 promoters to determine the percentage of Kiss1-expressing neurons that co-express the ERα in the MeA and, whether those cells are activated by olfactory cues. We found a high percentage of Kiss1-expressing neurons in the MeA co-expressing the ERα. The proporti...Continue Reading

References

May 1, 1975·The Journal of Comparative Neurology·F Scalia, S S Winans
Sep 18, 1995·The Journal of Comparative Neurology·N S CanterasL W Swanson
Apr 20, 2002·Journal of Neuroendocrinology·G E Hoffman, D Lyo
Sep 3, 2003·Progress in Neurobiology·Mimi Halpern, Alino Martínez-Marcos
May 28, 2005·Endocrinology·Jeremy T SmithRobert A Steiner
Nov 17, 2006·Nature·Peter A Brennan, Frank Zufall
Jun 5, 2007·Physiology & Behavior·Kassandra L Edinger, Cheryl A Frye
Oct 28, 2009·Physiology & Behavior·Jose DonatoCarol Fuzeti Elias
Nov 26, 2010·Neuroscience·R M CravoC F Elias
Mar 3, 2011·Endocrinology·Joshua KimAlexander S Kauffman
Mar 19, 2013·PloS One·Roberta M CravoCarol F Elias
Mar 12, 2015·Brain Structure & Function·Alexander N ComninosWaljit S Dhillo
May 29, 2016·Neuroscience Letters·Rebecca GreshamKevin T O'Byrne
Sep 25, 2016·Journal of Neuroendocrinology·S-H YeoW H Colledge
Jan 24, 2017·The Journal of Clinical Investigation·Alexander N ComninosWaljit S Dhillo
Mar 28, 2017·Molecular and Cellular Endocrinology·Marina Augusto SilveiraRenata Frazao
Aug 22, 2017·Frontiers in Endocrinology·Shannon B Z Stephens, Alexander S Kauffman
Aug 29, 2017·PloS One·Daniel A AdekunbiKevin T O'Byrne

❮ Previous
Next ❯

Citations

Apr 10, 2019·Journal of Neuroendocrinology·Xiao Feng LiKevin T O'Byrne

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.