PMID: 372155Jan 22, 1979Paper

Constancy and variability in the content of DNA in cerebellar Purkinje cell nuclei. A cytophotometric study

Histochemistry
V Y BrodskyE A Lebedev

Abstract

A cytophotometric study of DNA content in Purkinje cells of the cerebellum of rats, cats, chicken and humans (Feulgen staining) revealed that in a certain number of cells the amount of NDA ranged between the diploid and tetraploid level (H2C cells). The incidence of H2C Purkinje cells varied among the species studied. In rats, which were studied most thoroughly, these cells amounted on average to 3%. In some rats, as well as in some cats and chickens H2C Purkinje cells were entirely absent. In the group of animals possesing H2C Purkinje cells, great interindividual differences were observed. In rats for instance, the incidence of these cells varied from 1 to 23 per cent. Topographic analyses carried out in rat and human cerebellum revealed that H2C Purkinje cells occurred more frequently in the hemispheres than in the vermis. No significant differences were found in the number of H2C Purkinje cells in healthy and Kilham-DNA-virus infected rats. Densitometric analysis of the distribution of nuclear chromatin showed that H2C Purkinje cells were richer in condensed chromatin, especially in the region of the nucleolus, which apparently contains the hyperploid surplus of DNA. It is proposed that the phenomenon of DNA hyperdiploidy a...Continue Reading

References

Apr 1, 1975·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L R TrusalJ J Docherty
Jan 1, 1977·International Review of Cytology·W Y Brodsky, I V Uryvaeva
Jan 1, 1975·Histochemistry·A BregnardC C Kuenzle
May 1, 1976·Journal of Neurobiology·R C Bohn, R B Mitchell
Feb 1, 1973·Journal of the Neurological Sciences·D M Mann, P O Yates
Jan 1, 1973·Histochemie. Histochemistry. Histochimie·S Fujita

Citations

Apr 1, 1982·Biulleten' eksperimental'noĭ biologii i meditsiny·Z A Mikeladze, V Ia Brodskiĭ
Apr 1, 1983·Biulleten' eksperimental'noĭ biologii i meditsiny·V Ia BrdskiĭG N Moskovkin
Aug 1, 1980·Neurochemical Research·M WintzerithP Mandel
Apr 25, 2012·Molecular Neurobiology·Thomas Arendt
Aug 1, 1988·Cell Differentiation·V Y BrodskyE A Braga
Jan 1, 1988·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M G Giacobini RobecchiG Filogamo
Jan 1, 1990·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A PoncinoG Filogamo
Mar 11, 2006·The Cerebellum·Ugo Del Monte
Apr 19, 2012·Aging Cell·Hans-Georg FischerThomas Arendt
Apr 8, 1987·The Journal of Comparative Neurology·B G Szaro, R Tompkins
Jul 1, 1981·Cell and Tissue Kinetics·N BöhmE Kaiser
Sep 1, 1984·American Journal of Medical Genetics·P R ScarbroughB W Althaus
Sep 23, 1998·Experimental Cell Research·V ShneyvaysA Shainberg
Apr 12, 2017·Journal of Neurochemistry·Thomas ArendtUwe Ueberham

Related Concepts

Metazoa
Felis catus
Cell Nucleus
Cerebellum
Chick Embryo
Chromatin
Cytological Techniques
DNA, Double-Stranded
Photometry
Purkinje Cells

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