Constant amplitude of postsynaptic responses for single presynaptic action potentials but not bursting input during growth of an identified neuromuscular junction in the lobster, Homarus americanus

Journal of Neurobiology
Stefan R PulverEve Marder

Abstract

As lobsters grow from early juveniles to adults their body size increases more than 20-fold, raising the question of how function is maintained during these ongoing changes in size. To address this question we studied the pyloric 1 (p1) muscle of the stomach of the lobster, Homarus americanus. The p1 muscle receives multiterminal innervation from one motor neuron, the lateral pyloric neuron of the stomatogastric ganglion. Staining with antibodies raised against synaptotagmin showed that as the muscle fibers increased in length, the spacing between the terminal innervation increased proportionally, so the number of synaptic contact regions/muscle fiber did not change. Muscle fibers were electrically coupled in both juveniles and adults. The amplitude of single intracellularly recorded excitatory junctional potentials evoked by motor nerve stimulation was the same in both juveniles and adults. Nonetheless, the peak depolarizations reached in response to ongoing pyloric rhythm activity or in response to high-frequency trains of stimuli similar to those produced during the pyloric rhythm were approximately twofold larger in juveniles than in adults. This suggests that homeostatic regulation of synaptic connections may operate at th...Continue Reading

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Citations

Dec 8, 2009·Nature Neuroscience·Stefan R Pulver, Leslie C Griffith
Nov 24, 2004·Nature Neuroscience·Astrid A PrinzEve Marder
Sep 18, 2013·Proceedings of the National Academy of Sciences of the United States of America·Maarten F ZwartMatthias Landgraf
Jun 17, 2006·Annual Review of Neuroscience·Graeme W Davis
Nov 9, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nelly DaurDirk Bucher
Jun 23, 2006·Nature Reviews. Neuroscience·Eve Marder, Jean-Marc Goaillard
Jan 18, 2007·The Journal of Comparative Neurology·Dirk BucherEve Marder
Oct 1, 2020·Scientific Reports·Srinivas Gorur-ShandilyaTimothy O'Leary

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