Constant infusion rates of lipid emulsions to stabilize plasma triglyceride concentrations: medium-chain triglyceride/long-chain triglyceride emulsions (MCT/LCT) versus LCT

Surgery Today
K IriyamaC Shigemori

Abstract

As medium-chain triglyceride emulsions (MCT) are more rapidly hydrolyzed than long-chain triglyceride emulsions (LCT), MCT/LCT tends to be infused faster than LCT. The purpose of the present study was to determine the most appropriate infusion rate for MCT/LCT to stabilize plasma concentrations of triglyceride (TG), being equivalent to the optimal infusion rate of the emulsion. A TG clamp was set up by raising the mean +/- SD concentrations of TG in plasma, being 1.08 +/- 0.18 delta mmol l(-1) for LCT, and 1.65 +/- 0.31 delta mmol l(-1) for MCT/LCT after a 50-min priming infusion of each emulsion. Thereafter, the infusion rate of lipid was controlled every 10 min to maintain a steady concentration of TG for a period of 150 min. A constant infusion of glucose at 0.32 g/kg body weight (BW) per h was administered for the test period. The weight-based rate of the infusion to maintain a steady state of plasma TG concentrations did not differ between MCT/LCT and LCT, being 0.125 +/- 0.013 vs 0.117 +/- 0.021 g/kg BW per h, while the molar-based infusion rate was 0.203 +/- 0.021 mmol/kg BW per h for MCT/LCT and 0.132 +/- 0.023 mmol/kg BW per h for LCT (P < 0.05). These results suggest that although 54% more molar MCT/LCT-TG can be hydr...Continue Reading

References

May 1, 1992·JPEN. Journal of Parenteral and Enteral Nutrition·S T Fan, J Wong
Dec 1, 1991·European Journal of Clinical Investigation·J NordenströmJ Wahren
Sep 1, 1990·JPEN. Journal of Parenteral and Enteral Nutrition·G L JensenB R Bistrian
Mar 1, 1994·JPEN. Journal of Parenteral and Enteral Nutrition·A De GaetanoA V Greco
Jul 1, 1996·The British Journal of Surgery·K IriyamaY A Carpentier
Apr 1, 1996·Nutrition·H UlrichV Kvetan

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Citations

Apr 16, 2002·European Journal of Clinical Investigation·G J A WantenA H J Naber
Jun 29, 2006·JPEN. Journal of Parenteral and Enteral Nutrition·Dan L WaitzbergThiago Manzoni Jacintho
Aug 2, 2007·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Hiroshi IwakiSusumu Ito

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