Constant-variable flip angles for hyperpolarized media MRI

Journal of Magnetic Resonance
He DengXin Zhou

Abstract

The longitudinal magnetization of hyperpolarized media, such as hyperpolarized (129)Xe, (3)He, etc., is nonrenewable. When the MRI data acquisition begins at the k-domain center, a constant flip angle (CFA) results in an image of high signal-to-noise ratio (SNR) but sacrifices the accuracy of spatial information. On the other hand, a variable flip angle (VFA) strategy results in high accuracy but suffers from a low SNR. In this paper, we propose a novel scheme to optimize both the SNR and accuracy, called constant-variable flip angles (CVFA). The proposed scheme suggests that hyperpolarized magnetic resonance signals are firstly acquired through a train of n(∗) CFA excitation pulses, followed by a train of N-n(∗) VFA excitation pulses. We simulate and optimize the flip angle used in the CFA section, the number of CFA excitation pulses, the number of VFA excitation pulses, and the initial and final variable flip angles adopted in the VFA section. Phantom and in vivo experiments demonstrate the good performance of the CVFA designs and their ability to maintain both high SNR and spatial resolution.

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Citations

Dec 28, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Weiwei RuanXin Zhou
Jul 30, 2016·Journal of Magnetic Resonance Imaging : JMRI·Weiwei RuanXin Zhou
Jul 20, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Caohui DuanXin Zhou
Mar 9, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peter J NiedbalskiZackary I Cleveland
Feb 27, 2021·Progress in Nuclear Magnetic Resonance Spectroscopy·Helen MarshallJim M Wild

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