Constipation in cancer patients on morphine

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Joanne DroneyJulia Riley

Abstract

Constipation is a significant problem in patients taking morphine for cancer pain. The aims of this study were (1) to assess the magnitude of constipation in this study cohort, (2) to analyse the constipation treatment strategies and (3) to look for evidence of inter-individual variation in both susceptibility to constipation and response to treatment with laxatives in this patient group. This was an observational study carried out in a tertiary referral cancer hospital. Two hundred seventy four patients were recruited to the study. All had a diagnosis of cancer and were on oral morphine for cancer pain. The main outcomes measured were subjective patient assessment of constipation severity in the preceding week and laxative use. Patients were asked to grade constipation in the preceding week on a four-point categorical scale: "not at all" (grade 0), "a little" (grade 1), "quite a bit" (grade 2) and "very much" (grade 3). Laxative dose groups (LDGs) were developed to assess laxative dosing. Constipation affects 72% of this cohort of patients. Constipation in this population is poorly managed. Eighty nine percent of constipated patients were on inadequate laxative therapy. Inter-individual variation in constipation on morphine ex...Continue Reading

References

Jul 1, 1992·Journal of Pain and Symptom Management·S A SchugB Stobbe
Jun 1, 1989·Cancer Nursing·S C McMillan, F A Williams
Mar 1, 1987·The Medical Clinics of North America·R K Portenoy
Apr 1, 1996·Family Practice·M J HerzS Reichman
Jun 1, 1996·Journal of Pain and Symptom Management·N P Sykes
Aug 6, 1998·Cancer Nursing·G VanegasF De Conno
Aug 8, 1998·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·I Mancini, E Bruera
Dec 10, 1998·Journal of Pain and Symptom Management·K W SchuitB Meyboom-de Jong
Sep 4, 1999·Palliative Medicine·M T Fallon, G W Hanks
May 2, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N ChernyUNKNOWN Expert Working Group of the European Association of Palliative Care Network
Jan 5, 2002·American Journal of Surgery·M Pappagallo
Aug 31, 2002·International Journal of Clinical Oncology·Robert G Twycross
Jun 18, 2003·The American Journal of Gastroenterology·Nicholas J TalleyDominique Dubois
Jun 14, 2005·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Julia RileyKen Welsh
Apr 11, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Rachel J Gibson, Dorothy M K Keefe
Oct 21, 2006·The Cochrane Database of Systematic Reviews·C L MilesS Wilkinson
Apr 13, 2007·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Rachel P RiechelmannCamilla Zimmermann
Nov 15, 2007·Clinical & Experimental Ophthalmology·Charles N J McGhee

❮ Previous
Next ❯

Citations

Aug 10, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Antonio NogueraMaría Nabal
Dec 1, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Eivor A LaugsandPål Klepstad
Jun 2, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Lars Morten SkollerudPetter C Borchgrevink
Jun 2, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Chung Wah ChengDoris Mw Tse
Jan 23, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Gemma CramarossaAndrew Bottomley
Jun 3, 2011·Journal of Palliative Medicine·Patricia Papa, Leticia Turconi
Apr 22, 2010·The Journal of Pharmacology and Experimental Therapeutics·Guijun FeiJackie D Wood
Dec 2, 2011·The Journal of Pharmacology and Experimental Therapeutics·Minho KangHamid I Akbarali
Jan 1, 2009·Journal of Pain Research·Joanne Droney, Julia Riley
Aug 13, 2011·Clinical Medicine Insights. Oncology·S BaderG Becker
Jan 1, 2011·Case Reports in Medicine·Naomi KishineTomohisa Shoko
Dec 25, 2010·Digestive Diseases and Sciences·Xiaohong SunJackie D Wood
Mar 29, 2011·Hospital Practice·Felix W Leung, Satish S C Rao
Jun 11, 2015·Scandinavian Journal of Gastroenterology·Bishal GyawaliYuichi Ando
Sep 4, 2012·Journal of Pain and Symptom Management·Katherine Clark, David C Currow
Jul 28, 2012·Journal of Pain and Symptom Management·Wadih RhondaliEduardo Bruera
Jan 18, 2012·Journal of Pain and Symptom Management·Robert TwycrossAndrew Wilcock
Sep 14, 2010·Journal of Pain and Symptom Management·Sebastiano MercadanteAlessandra Casuccio
Mar 28, 2012·Journal of Pain & Palliative Care Pharmacotherapy·Olayinka R EyeladeOluranti A Akinyemi
Jun 19, 2015·Clinical and Translational Gastroenterology·Eivor A LaugsandPål Klepstad
May 5, 2016·Digestive Diseases and Sciences·Jackie D Wood
Sep 24, 2011·Journal of Pediatric Hematology/oncology·Farzana D PashankarDinesh S Pashankar
Aug 14, 2012·International Journal of Palliative Nursing·A Dal MolinL Rasero
Oct 25, 2013·International Journal of Palliative Nursing·Amanda Andrews, Gwyneth Morgan
Feb 7, 2012·International Journal of Palliative Nursing·Amanda Andrews, Gwyneth Morgan
Jul 22, 2017·Current Medical Research and Opinion·Sebastiano MercadanteFederica Aielli
May 15, 2015·The Cochrane Database of Systematic Reviews·Bridget CandyPatrick Stone
Apr 14, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Biao XuQuan Fang
Apr 1, 2016·Scandinavian Journal of Pain·Helene Nordahl ChristensenHarald Breivik
Jul 30, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Perry G FineCatherine Datto
Jul 27, 2012·Journal of Wound, Ostomy, and Continence Nursing : Official Publication of the Wound, Ostomy and Continence Nurses Society·Carol StottGreg Fairbrother
Jun 11, 2009·Current Opinion in Oncology

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Clinical Practice
S J PanchalJ I Wurzelmann
The New England Journal of Medicine
Jay ThomasRobert J Israel
Journal of Pain and Symptom Management
Jay Thomas
Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
H U De SchepperM Camilleri
© 2021 Meta ULC. All rights reserved