Constipation is not associated with dopamine transporter pathology in early drug-naïve patients with Parkinson's disease

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
G PaganoM Politis

Abstract

Constipation is a common non-motor symptom of Parkinson's disease (PD). Deposition of α-synuclein inclusions that spread from the gut to the substantia nigra through the vagus nerve has recently been speculated to be a pre-motor and early stage of PD. The aim of the study was to investigate whether constipation is associated with dopaminergic pathology on dopamine transporter (DAT) single-photon emission computed tomography in early drug-naïve patients with PD. Our hypothesis was that constipation is associated with other signs of pre-motor PD and is independent of DAT pathology. We then investigated for associations with motor and non-motor symptoms, and with cerebrospinal fluid biomarkers of PD pathology. Using the Parkinson's Progression Markers Initiative database, we investigated the prevalence of constipation and the association between constipation and clinical features, striatal [123 I]Ioflupane uptake and non-imaging (cerebrospinal fluid and serum) biomarkers. Constipation was evaluated using Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part I item 1.11. One third (132/398) of de-novo patients with PD had constipation. Higher severity of constipation correlate...Continue Reading

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Citations

Jul 12, 2020·Journal of Clinical Medicine·Rosalind M TuckerR John Dobbs
Oct 17, 2018·Frontiers in Neurology·Tayyabah YousafMarios Politis
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Feb 8, 2021·Parkinsonism & Related Disorders·Deepika DineshNatalia Palacios
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Jun 17, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Marta CamachoCaroline H Williams-Gray
Dec 10, 2021·Aging and Disease·Yu LiWeidong Le

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