Constituents isolated from Cordyceps militaris suppress enhanced inflammatory mediator's production and human cancer cell proliferation

Journal of Ethnopharmacology
Yerra Koteswara RaoYew-Min Tzeng

Abstract

The purpose of this study is to isolate the pure compounds from the extracts of Cordyceps militaris obtained through solid-state cultivation process, and evaluate their anti-inflammatory and anticancer properties. Silica gel column chromatographic purification of Cordyceps militaris extracts resulted in the isolation of 10 pure compounds (1-10). The compounds 1-10 were examined for their growth inhibitory properties against nitric oxide (NO), tumor necrosis factor (TNF)-alpha and interleukin (IL)-12 enhanced production from LPS/IFN-gamma-stimulated macrophages. Additionally, the anti-proliferation effects of 1-10 on human cancer cell lines, colon (colon 205), prostate (PC-3), and hepatoma (HepG2) cells were also analyzed. Compound 8 displayed potent growth inhibition on NO, TNF-alpha and IL-12 production with an IC(50) value of 7.5, 6.3, and 7.6 microg/ml, respectively. A similar inhibitory trend on these inflammatory mediators was observed for 3, 7, 9 and 10 with an IC(50) values ranging from 10.8 to 17.2 microg/ml. On the other hand, compounds 3 and 8 were potent anti-proliferative agents with an IC(50) value of 35.6 and 32.6 microg/ml toward PC-3 and colon 205 cell lines, respectively. The compounds 1 and 2 showed potent ant...Continue Reading

References

Nov 18, 1971·The New England Journal of Medicine·J Folkman
May 17, 2005·Journal of Ethnopharmacology·Yerra Koteswara RaoYew-Min Tzeng
Sep 20, 2005·Journal of Ethnopharmacology·Yerra Koteswara RaoYew-Min Tzeng
Apr 6, 2006·Biological & Pharmaceutical Bulletin·Haemi LeeTaesun Park
May 4, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yerra Koteswara RaoYew-Min Tzeng
Oct 22, 2008·Journal of Ethnopharmacology·Chun Sung KimDo Kyung Kim
Nov 5, 2008·The Journal of Clinical Investigation·Fionula M Brennan, Iain B McInnes
Dec 2, 2008·Journal of Ethnopharmacology·Yerra Koteswara RaoYew-Min Tzeng
Sep 8, 2009·Current Opinion in Pharmacology·Dingzhi WangAnn Richmond
Oct 17, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Se-Jung LeeSung-Kwon Moon

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Citations

Sep 1, 2011·Journal of Medicinal Food·Maria MakropoulouNikolas Fokialakis
Oct 15, 2013·Life Sciences·Hardeep S TuliDharambir Kashyap
May 15, 2012·3 Biotech·Seema Patel, Arun Goyal
Oct 30, 2014·Molecular Medicine Reports·Yuan DongLirong Teng
Feb 17, 2015·International Journal of Microbiology·María Elena ValverdeOctavio Paredes-López
Mar 14, 2019·Journal of Medicinal Food·Nguyen Khoi Song TranTae-Sik Park
Apr 28, 2012·British Journal of Pharmacology·Shuhei TakahashiMasanori Kitamura
Mar 16, 2013·The Journal of Pharmacy and Pharmacology·Kai YueXiao Lin
Oct 11, 2019·Journal of Food Biochemistry·Ebru DeveciMehmet Öztürk
Sep 6, 2019·International Journal of Cancer. Journal International Du Cancer·Shu ZhangIchiro Tsuji
Sep 3, 2020·Applied Microbiology and Biotechnology·Angela BiancoGiacomo Zara
Aug 2, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Jae Gwang ParkJae Youl Cho
May 17, 2019·Food Science and Biotechnology·Mei Tong HeEun Ju Cho
May 16, 2017·Natural Product Research·Jinfeng SunGao Li
Feb 26, 2021·Frontiers in Pharmacology·Gitishree DasJayanta Kumar Patra
Feb 26, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Ho-Sung LeeDae-Yeon Lee

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