PMID: 7087697Mar 1, 1982Paper

Constituents of human meconium: II. Identification of steroidal acids with 21 and 22 carbon atoms

J St PyrekE W Adcock


Monohydroxylated acid fraction isolated from human meconium was found to contain, in addition to C20 and C24 acids identified previously, three C22 bile acids-(20S)-3 alpha-hydroxy-23,24-bisnor-5 beta-cholan-22-oic, (20S)- and (20R)-3 beta-hydroxy-23,24-bisnor-chol-5-en-22-oic, and one C21 acid-3 beta-hydroxypregn-5-en-21-oic. These compounds were identified by capillary gas chromatography-mass spectrometry and by comparison with standards. It is postulated that these C22 acids, as well as the two monohydroxylated C24 bile acids (lithocholic and 3 beta-hydroxychol-5-enoic) are produced in the maternal intestine by microbial flora and transferred to the fetus through the placenta.


Jan 1, 1977·Advances in Applied Microbiology·C K Martin
Aug 1, 1977·Journal of Steroid Biochemistry·C Monder, H L Bradlow
Jun 15, 1979·FEBS Letters·M E TennesonA N Mason
Mar 1, 1979·Journal of Steroid Biochemistry·M E TennesonA N Mason
Sep 1, 1979·Journal of Steroid Biochemistry·M E TennesonA N Mason
Dec 15, 1979·The Biochemical Journal·M E TennesonA N Mason
Jul 1, 1978·FEBS Letters·M E TennesonA N Mason
Jan 1, 1978·Biochemical Society Transactions·M E TennesonA N Mason
Feb 18, 1977·The Journal of Organic Chemistry·S G WyllieL Tökés
Jan 1, 1975·Fortschritte der Chemie organischer Naturstoffe = Progress in the chemistry of organic natural products. Progrès dans la chimie des substances organiques naturelles·W K Seifert
Mar 1, 1976·Steroids·E D Bergmann, A Solomonovici
Jun 1, 1971·The Journal of Clinical Endocrinology and Metabolism·R A Kinsella, F E Francis
Oct 1, 1974·Journal of Steroid Biochemistry·P Goddard, M J Hill
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Jan 1, 1973·Hoppe-Seyler's Zeitschrift für physiologische Chemie·P Back, K Ross
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Jul 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·A Norman, M S SHORB

Related Concepts

Bile Salts
High Pressure Liquid Chromatography Procedure
Chromatography, Gas-Liquid-Mass Spectrometry
Catatoxic Steroids

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