PMID: 7087697Mar 1, 1982Paper

Constituents of human meconium: II. Identification of steroidal acids with 21 and 22 carbon atoms

Lipids
J St PyrekE W Adcock

Abstract

Monohydroxylated acid fraction isolated from human meconium was found to contain, in addition to C20 and C24 acids identified previously, three C22 bile acids-(20S)-3 alpha-hydroxy-23,24-bisnor-5 beta-cholan-22-oic, (20S)- and (20R)-3 beta-hydroxy-23,24-bisnor-chol-5-en-22-oic, and one C21 acid-3 beta-hydroxypregn-5-en-21-oic. These compounds were identified by capillary gas chromatography-mass spectrometry and by comparison with standards. It is postulated that these C22 acids, as well as the two monohydroxylated C24 bile acids (lithocholic and 3 beta-hydroxychol-5-enoic) are produced in the maternal intestine by microbial flora and transferred to the fetus through the placenta.

References

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Related Concepts

Bile Salts
High Pressure Liquid Chromatography Procedure
Chromatography, Gas-Liquid-Mass Spectrometry
Meconium
Catatoxic Steroids

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