Constituents of Senecio chionophilus with potential antitubercular activity

Journal of Natural Products
Jian-Qiao GuBarbara N Timmermann

Abstract

Two new sesquiterpenoids, (1S,4S,5R,10R)-1-hydroxy-6-isobutyryloxy-10H-9-oxofuranoeremophilane (1) and 1alpha-hydroxy-6beta-(2xi-methylbutyryloxy)-10alphaH-9-oxofuranoeremophilane (2), along with 21 known constituents, were isolated from the n-hexane and dichloromethane extracts of the above-ground biomass and roots of Senecio chionophilus. The structures of 1 and 2 were elucidated on the basis of spectroscopic evidence and chemical transformation methods. The absolute configuration of 1 was determined by Mosher ester methodology. All of the isolates were evaluated for their antitubercular potential against Mycobacterium tuberculosis in a microplate Alamar Blue assay. Compound 2, 6beta-angeloyloxy-1alpha-hydroxy-10alphaH-9-oxofuranoeremophilane (3), and 4'-hydroxyacetophenone (6) exhibited mild antitubercular activity at minimum inhibitory concentrations of 119, 114, and 121 microg/mL, respectively.

References

Sep 1, 1988·Journal of Animal Science·P R Cheeke
Dec 4, 2001·Planta medica·C L CantrellN H Fischer

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Citations

May 7, 2011·Archives of Pharmacal Research·Yann-Lii LeuPing-Chung Kuo
Jul 28, 2005·Natural Product Reports·Braulio M Fraga
Mar 17, 2012·Chemistry & Biodiversity·Matías ReinaAzucena González-Coloma
Aug 3, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Mohamed F AlajmiJamal M Khaled
Jan 25, 2011·Chemistry & Biodiversity·Yan YangHiromasa Kiyota

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