Constitutive Activation of MexT by Amino Acid Substitutions Results in MexEF-OprN Overproduction in Clinical Isolates of Pseudomonas aeruginosa

Antimicrobial Agents and Chemotherapy
Paulo JuarezCatherine Llanes

Abstract

When overproduced, the multidrug efflux system MexEF-OprN increases the resistance of Pseudomonas aeruginosa to fluoroquinolones, chloramphenicol, and trimethoprim. In this work, we demonstrate that gain-of-function mutations in the regulatory gene mexT result in oligomerization of the LysR regulator MexT, constitutive upregulation of the efflux pump, and increased resistance in clinical isolates.

References

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Feb 3, 2016·Antimicrobial Agents and Chemotherapy·Charlotte RichardotCatherine Llanes

Citations

Dec 21, 2019·Journal of Medical Microbiology·Eric D LoVullo, H P Schweizer
Jul 31, 2019·Journal of Bacteriology·Ian T HillSimon L Dove
Apr 24, 2018·Frontiers in Microbiology·Carla López-CausapéAntonio Oliver
Jul 5, 2018·Frontiers in Molecular Biosciences·Karim Housseini B IssaIsabelle Broutin

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