Constitutive beta-catenin activation induces adrenal hyperplasia and promotes adrenal cancer development

Human Molecular Genetics
Annabel BerthonPierre Val

Abstract

Adrenocortical carcinoma is a rare but aggressive cancer with unknown aetiology. Constitutive activation of beta-catenin is the most frequent alteration in benign and malignant adrenocortical tumours in patients. Here, we show that constitutive activation of beta-catenin in the adrenal cortex of transgenic mice resulted in progressive steroidogenic and undifferentiated spindle-shaped cells hyperplasia as well as dysplasia of the cortex and medulla. Over a 17 months time course, transgenic adrenals developed malignant characteristics such as uncontrolled neovascularization and loco-regional metastatic invasion. These oncogenic events were accompanied by ectopic differentiation of glomerulosa at the expense of fasciculata cells, which caused primary hyperaldosteronism. Altogether these observations demonstrate that constitutively active beta-catenin is an adrenal oncogene which triggers benign aldosterone-secreting tumour development and promotes malignancy.

References

Apr 1, 1994·Clinical Endocrinology·C GicquelY Le Bouc
Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·M M MatzukA Bradley
Nov 1, 1993·Nature Genetics·M HarveyL A Donehower
Jan 1, 1997·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S Dickman
May 1, 1997·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C GicquelM Schlumberger
Feb 7, 1998·Genes & Development·K M Cadigan, R Nusse
Aug 6, 1998·Virchows Archiv : an International Journal of Pathology·D P Magennis, A M McNicol
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·M ShtutmanA Ben-Ze'ev
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Aug 26, 2000·Cytokine & Growth Factor Reviews·T Akiyama
Nov 1, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·N Barker, H Clevers
Jan 13, 2001·Diseases of the Colon and Rectum·T G SmithR K Phillips
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·R C RibeiroR Sandrini
Aug 15, 2001·The Journal of Clinical Endocrinology and Metabolism·C MartinerieY Le Bouc
Jan 26, 2002·Molecular and Cellular Biology·Barbara LustigJürgen Behrens
Aug 21, 2002·Trends in Endocrinology and Metabolism : TEM·Catherine E Keegan, Gary D Hammer
Jan 28, 2003·The American Journal of Pathology·Thomas J GiordanoSamir M Hanash
Mar 12, 2003·The Journal of Clinical Endocrinology and Metabolism·Marie-Hélène BernardChristine Gicquel
Nov 5, 2003·Nuclear Receptor·Pierre ValAntoine Martinez
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Anne-Marie Lefrançois-MartinezAntoine Martinez
Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Ann T SweeneyGeorge L Tully
Jan 26, 2005·Endocrine Research·S KiiveriM Heikinheimo
Apr 19, 2005·Genes & Development·Alex Gregorieff, Hans Clevers
Nov 2, 2005·European Journal of Endocrinology·L BarzonG Palù
Feb 4, 2006·The American Journal of Gastroenterology·Polymnia Galiatsatos, William D Foulkes
Mar 23, 2006·The Journal of Clinical Endocrinology and Metabolism·Bruno Allolio, Martin Fassnacht
Jun 3, 2006·Developmental Cell·Samira BenhamoucheSabine Colnot
Jan 20, 2007·Cancer Research·Alina Nico WestGerard P Zambetti
Feb 10, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rossella LibèJérôme Bertherat
Sep 1, 2007·Molecular Endocrinology·Mabrouka DoghmanEnzo Lalli
Jun 12, 2008·The Journal of Clinical Endocrinology and Metabolism·Mabrouka DoghmanEnzo Lalli

❮ Previous
Next ❯

Citations

Nov 4, 2010·Current Opinion in Oncology·Kimberly J Bussey, Michael J Demeure
Nov 6, 2012·Journal of Oncology·Amir H LebastchiTobias Carling
Mar 20, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Derek P SimonGary D Hammer
Feb 23, 2012·The Journal of Clinical Investigation·Claire R HughesLouise A Metherell
Mar 31, 2012·Endocrinology·Justyna KrachulecDavid B Wilson
Jun 16, 2010·PLoS Genetics·Isabelle Sahut-BarnolaAntoine Martinez
Jan 8, 2011·The Oncologist·Lyndal J TaconStan B Sidhu
Apr 26, 2014·World Journal of Surgery·Chitra SubramanianMark Cohen
Nov 17, 2011·Virchows Archiv : an International Journal of Pathology·Ronald R de Krijger, Thomas G Papathomas
Jan 31, 2015·Neuro : Open Journal·Rachel D Aufforth, Naris Nilubol
Sep 23, 2014·Molecular and Cellular Endocrinology·Silvia MonticoneWilliam E Rainey
Nov 27, 2014·The Journal of Endocrinology·Maria-Christina ZennaroFabio Fernandes-Rosa
Jan 28, 2016·Scientific Reports·Tobias ÅkerströmPeyman Björklund
Dec 1, 2010·Best Practice & Research. Clinical Endocrinology & Metabolism·Delphine VezzosiLionel Groussin
Apr 5, 2012·Clinical Endocrinology·Tânia L MazzucoIsabelle Bourdeau
Dec 7, 2013·Clinical Endocrinology·Yunze XuYiran Huang
Jul 1, 2015·Frontiers in Endocrinology·Sheerazed BoulkrounMaria-Christina Zennaro
Jun 5, 2015·Frontiers in Cell and Developmental Biology·Annabel S BerthonConstantine A Stratakis
Mar 10, 2015·European Journal of Endocrinology·Anne ThielUte I Scholl
Mar 24, 2015·Frontiers in Endocrinology·Marjut PihlajokiDavid B Wilson
Dec 30, 2014·Molecular and Cellular Endocrinology·Coralie DrelonPierre Val
Jul 30, 2016·Frontiers in Endocrinology·Felicia LecciaAntoine Martinez
Jun 4, 2015·Endocrinology and Metabolism Clinics of North America·Stéphanie Espiard, Jérôme Bertherat
Aug 4, 2016·Endocrine-related Cancer·Ravi Kumar DuttaOliver Gimm
Jun 4, 2015·Endocrinology and Metabolism Clinics of North America·Sara Galac, David B Wilson
Apr 4, 2017·Oncogene·M Batisse-LignierA-M Lefrançois-Martinez
Apr 13, 2017·Journal of Molecular Endocrinology·Fabio Luiz Fernandes-RosaMaria-Christina Zennaro
Jun 2, 2015·Molecular and Cellular Endocrinology·Marjut PihlajokiDavid B Wilson
Nov 20, 2016·Acta Physiologica·S Bandulik
Dec 13, 2016·Molecular and Cellular Endocrinology·Morgan K PennyGary D Hammer
Nov 28, 2016·Molecular and Cellular Endocrinology·Carolin SchwafertzHolger S Willenberg
Oct 8, 2014·Nature Reviews. Endocrinology·Elisabeth M Walczak, Gary D Hammer
Mar 10, 2011·Nature Reviews. Endocrinology·Martin FassnachtBruno Allolio
Nov 17, 2017·Endocrine-related Cancer·Enzo Lalli, Michaela Luconi
Dec 14, 2017·Endocrine-related Cancer·Fidéline Bonnet-Serrano, Jérôme Bertherat

❮ Previous
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