Constitutive, but not inflammatory, cross-presentation is disabled in the pancreas of young mice

European Journal of Immunology
Justine D MinternWilliam R Heath

Abstract

Peripheral antigens can be captured by APC and cross-presented to naive CD8(+) T cells. Notably, cross-presentation of pancreatic antigen is not seen in neonatal mice, although presentation of antigen expressed by the kidney is still intact. In this report, we examined why pancreatic antigens are not cross-presented in neonatal mice. First, we established that antigen expression was not limiting, as neonatal islets expressed as much antigen per cell as adult islets, and vastly more than neonatal renal cells. Next, we analyzed the APC subsets present in the lymph node draining the neonatal pancreas. No obvious population was absent. Finally, we examined whether cross-presentation occurred during inflammation. This showed that inflammation caused by CTL attack of islet tissue facilitated cross-presentation of antigens in neonatal mice. These data indicate that constitutive cross-presentation of islet antigens is inactive during neonatal life, but that under inflammatory conditions this antigen presentation pathway becomes available.

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Citations

Jul 12, 2007·Seminars in Immunopathology·Prisca SchulerBertrand Huard
Apr 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Boris CalderonEmil R Unanue
Nov 19, 2003·The Journal of Experimental Medicine·Shannon TurleyDiane Mathis
Jan 1, 2012·The Review of Diabetic Studies : RDS·Kate L GrahamThomas W H Kay
Oct 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marie-Claude GagneraultFrançoise Lepault
Feb 2, 2006·Immunological Reviews·Alena M Gallegos, Michael J Bevan
Dec 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Natalia Martin-OrozcoChen Dong
Dec 7, 2013·European Journal of Immunology·Natalia ZiętaraSiegfried Weiss
Dec 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Natalia Martin-OrozcoChristophe Benoist

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