Constitutive calcium entry and cancer: updated views and insights

European Biophysics Journal : EBJ
Olivier MignenChristophe Vandier

Abstract

Tight control of basal cytosolic Ca(2+) concentration is essential for cell survival and to fine-tune Ca(2+)-dependent cell functions. A way to control this basal cytosolic Ca(2+) concentration is to regulate membrane Ca(2+) channels including store-operated Ca(2+) channels and secondary messenger-operated channels linked to G-protein-coupled or tyrosine kinase receptor activation. Orai, with or without its reticular STIM partner and Transient Receptor Potential (TRP) proteins, were considered to be the main Ca(2+) channels involved. It is well accepted that, in response to cell stimulation, opening of these Ca(2+) channels contributes to Ca(2+) entry and the transient increase in cytosolic Ca(2+) concentration involved in intracellular signaling. However, in various experimental conditions, Ca(2+) entry and/or Ca(2+) currents can be recorded at rest, without application of any experimental stimulation. This led to the proposition that some plasma membrane Ca(2+) channels are already open/activated in basal condition, contributing therefore to constitutive Ca(2+) entry. This article focuses on direct and indirect observations supporting constitutive activity of channels belonging to the Orai and TRP families and on the mechanis...Continue Reading

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Citations

Dec 19, 2018·International Journal of Molecular Sciences·Isaac JardinJuan A Rosado
Mar 20, 2019·Cancers·Philippe KischelHalima Ouadid-Ahidouch
Oct 23, 2019·World Journal of Gastroenterology : WJG·Kyle J AndersonPatricia M Scott
May 10, 2018·Frontiers in Cellular Neuroscience·Przemysław KurowskiPaweł Szulczyk
Feb 12, 2021·Biophysics Reviews·Stephen J P PrattStuart S Martin
Jan 19, 2021·BioMed Research International·Hanwen ZhangWei Li
Jan 14, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Alban GiraultHalima Ouadid-Ahidouch
Oct 14, 2019·Cell Calcium·Mathieu GautierHalima Ouadid-Ahidouch
Jun 15, 2019·Cell Calcium·Sana KoubaMarie Potier-Cartereau
May 1, 2021·Cancers·Muhammad Yasir AsgharKid Törnquist
Jul 3, 2021·Genes·Mohamed ChamlaliHalima Ouadid-Ahidouch

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Methods Mentioned

BETA
xenografts
coimmunoprecipitation
time-resolved fluorescence resonance
transfection

Software Mentioned

STIM2

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