PMID: 2495533Apr 1, 1989Paper

Constitutive endocytosis of HLA class I antigens requires a specific portion of the intracytoplasmic tail that shares structural features with other endocytosed molecules

Proceedings of the National Academy of Sciences of the United States of America
M A Vega, J L Strominger

Abstract

HLA class I antigens present in the human leukemia T-cell line HPB-ALL are shown to be endocytosed in the absence of specific antibodies. In 1 hr, approximately 10% of class I molecules initially present at the cell surface are found intracellularly. Genetically engineered mutants of the HLA-A2 gene lacking exon 6 or 7 or both were used to analyze whether the cytoplasmic region contributes to the internalization. The results indicate that amino acids encoded by exon 7 (spanning amino acid residues 323-340) are required for internalization, while deletion of exon 6 had no effect. In addition, a comparison of the cytoplasmic sequences of receptors that are known to be internalized via coated pits and the present data revealed that they share a structural feature that could constitute a specific signal required for endocytosis.

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Citations

Mar 1, 1990·Journal of Cellular Physiology·M M Sczekan, R L Juliano
Dec 14, 2004·Springer Seminars in Immunopathology·Pierre Guermonprez, Sebastian Amigorena
Nov 7, 1993·Biochimica Et Biophysica Acta·M J Lohse
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Aug 30, 2002·Molecular Immunology·Monique Grommé, Jacques Neefjes
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Oct 1, 1996·Immunity·M JondalJ Reimann
Mar 15, 2001·Traffic·M J KleijmeerH J Geuze
Sep 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Xiuju LuRajat Varma
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M ValiquetteM Bouvier
Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A YokotaH Kikutani
May 1, 1990·The Journal of Cell Biology·P LemanskyA M Tartakoff
Nov 1, 1991·The Journal of Experimental Medicine·R LippéW A Jefferies
Oct 1, 1993·Scandinavian Journal of Immunology·U M Abdel MotalM Jondal
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Oct 17, 2012·PloS One·Ayako Demachi-OkamuraKiyotaka Kuzushima
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·I ChiuJ L Strominger
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·C M StoryH L Ploegh
Sep 23, 2014·Artificial Intelligence in Medicine·Gopal Krishna DhondalayMichael Hoare
Jul 16, 2005·Expert Opinion on Biological Therapy·Steve Pascolo

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