PMID: 9184642Jun 1, 1997Paper

Constitutive expression of costimulatory molecules by human microglia and its relevance to CNS autoimmunity

Journal of Neuroimmunology
F DangondD A Hafler

Abstract

Human microglia constitute the primary residential antigen presenting cells (APCs) in the central nervous system (CNS) and have the capacity of activating myelin reactive T-cells. T-cell activation requires two signals: first is the interaction of the T-cell receptor with the MHC-antigen complex and, secondly, contact of the CD28/CTLA4 T-cell surface molecules with the B7 family of costimulatory molecules on the APCs. We have previously shown high expression of B7.1 in early multiple sclerosis (MS) plaques, suggesting that acute T-cell-mediated CNS inflammation may require local B7.1 upregulation. We have now examined the expression of B7.1 and B7.2 costimulatory molecules on resting ex-vivo human microglia isolated directly from biopsy specimens. We found constitutive expression of B7.2 but not B7.1 on resting microglia, suggesting that B7.2 expression may lead to downregulation of pro-inflammatory Th1 T-cell responses in the normal brain.

References

May 18, 1989·Nature·S Kwok, R Higuchi
Feb 1, 1989·Journal of Neuroimmunology·Y GrenierJ P Antel
Dec 1, 1994·European Journal of Immunology·K WilliamsJ P Antel
Mar 1, 1995·Journal of Neuropathology and Experimental Neurology·R De SimoneF Aloisi
Jun 1, 1995·The Journal of Clinical Investigation·P S Linsley
Mar 1, 1993·The Journal of Experimental Medicine·M AzumaL L Lanier
May 5, 1997·The Journal of Experimental Medicine·K D BieganowskaD A Hafler

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Citations

Dec 14, 2011·Journal of Neurology·John N RatchfordPeter A Calabresi
Mar 9, 2004·Brain Research. Brain Research Reviews·Linda B Moran, Manuel B Graeber
Nov 12, 2003·The Journal of Allergy and Clinical Immunology·Tanuja Chitnis, Samia J Khoury
May 26, 1999·Progress in Neurobiology·G Stoll, S Jander
Dec 30, 1999·Microbes and Infection·J F Collawn, E N Benveniste
Jan 26, 1999·Cytokine & Growth Factor Reviews·E N Benveniste
May 20, 2003·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J C DebruyneJ L De Reuck
Aug 17, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·R KieferH P Hartung
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·J Roberto TrujilloJoseph D Brain
Jun 17, 1998·Journal of Neuroimmunology·F SellebjergL P Ryder
Nov 26, 2002·Journal of Neuroimmunology·Behnam BadieJill Schartner
Jan 7, 2011·Human Pathology·Alexandre Barcelos Morais da SilveiraAxel Brehmer
Jun 3, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kyra J BeckerZu-Cheng Ye
Oct 25, 2012·Journal of Neurochemistry·Kyra J Becker
Jul 16, 2013·Acta Neurologica Scandinavica·A VogelgesangA Dressel
Mar 7, 2002·International Reviews of Immunology·P H BasseR B Herberman
Mar 16, 2013·Journal of Neuroimmunology·Hui HuangSuhayl Dhib-Jalbut
Jan 31, 2007·Stroke; a Journal of Cerebral Circulation·J Michael GeeKyra J Becker
Jul 13, 1999·Microscopy Research and Technique·P Rezaie, D Male
Aug 12, 1999·Acta Neurologica Scandinavica·E Mena, C Rohowsky-Kochan
Jul 29, 2000·Seminars in Pediatric Neurology·I F PollackW H Chambers

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