PMID: 11322447Apr 27, 2001Paper

Constitutive expression of growth-related oncogene and its receptor in oligodendrogliomas

Neurosurgery
S RobinsonR H Miller

Abstract

Gliomas may result from transformation of glial precursor cells. In the developing rat central nervous system (CNS), a paracrine pathway involving the cytokines growth-related oncogene (GRO1) and platelet-derived growth factor (PDGF) A chain closely regulates oligodendrocyte precursor cell number. The purpose of the present study was to analyze whether abnormal expression and activity of the GRO1-PDGF pathway is present in human gliomas. Tumor specimens were studied to compare the messenger ribonucleic acid with the protein expression of components of the GRO1-PDGF pathway. Neutralizing antibodies were used in vitro to analyze whether the pathway contributed to tumor cell proliferation. Immunohistochemistry demonstrated that all components of the GRO1-PDGF pathway (GRO1 protein, its receptor CXCR2, PDGF A chain, and its receptor PDGFalphaR) were expressed by tumor cells in 6 (86%) of 7 of oligodendrogliomas as well as by 0 of 4 diffuse astrocytomas (World Health Organization Grades II and III) and 2 (18%) of 11 glioblastomas. Analysis by reverse transcriptase-polymerase chain reaction and enzyme-linked immunosorbent assay showed CXCR2 messenger ribonucleic acid and GRO1 protein expression were present in oligodendrogliomas. Fun...Continue Reading

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Citations

Mar 10, 2005·Neurobiology of Disease·Shenandoah RobinsonRobert H Miller
Nov 28, 2002·Surgical Neurology·Herbert H EngelhardElizabeth J Cochran
Sep 26, 2012·The Journal of Biological Chemistry·Ellen HukkelhovenAndrew Koff
Sep 16, 2011·Clinical Neurosurgery·Tiffany A Doucette, Ganesh Rao
Feb 2, 2012·Internal Medicine·Shigeru Kotake, Yuki Nanke
Jun 17, 2006·Journal of Neurosurgery·Shenandoah RobinsonMark L Cohen
Mar 27, 2012·Journal of Neuroimmunology·Mike Veenstra, Richard M Ransohoff
Jul 11, 2014·Cellular and Molecular Life Sciences : CMLS·Iva Simeonova, Emmanuelle Huillard
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Jul 27, 2010·Journal of Neuroimmunology·Giuseppe SciumèGiovanni Bernardini
Jul 21, 2009·Experimental Neurology·A E KerstetterR H Miller
Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·Christian HartmannAndreas von Deimling
Sep 12, 2013·PloS One·Veronica RondahlHåkan Hedman
Sep 25, 2018·Journal of Cellular and Molecular Medicine·Chang-Shuo HuangKuang-Hui Sun
Oct 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric RaymondUNKNOWN European Organisation for Research and Treatment of Cancer Brain Tumor Group Study
Oct 11, 2005·Neurosurgical Focus·Herbert H Engelhard

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