PMID: 11933047Apr 5, 2002Paper

Constitutive expression of heterologous N-methyl-D-aspartate receptor subunits in rat adrenal medulla

Journal of Neuroscience Research
E HinoiY Yoneda

Abstract

An RT-PCR analysis revealed constitutive expression of mRNA for N-methyl-D-aspartate (NMDA) receptor (NR)-1, NR-2C, and NR-2D subunits in rat adrenal and pituitary glands, in addition to brain and retina. Constitutive expression of mRNA was detected for the NR-2A subunit in pituitary but not adrenal gland. Although on Western blotting assays adrenal medulla exhibited expression of NR-1 subunit protein without expression of NR-2C and NR-2D subunit proteins, an immunohistochemical investigation clearly showed selective localization of proteins for NR-1, NR-2C, and NR-2D subunits in adrenal medulla but not in adrenal cortex. Prior treatment with different glycosidases invariably resulted in a marked increase in immunoreactivity to the anti-NR-1 antibody in both hippocampus and adrenal medulla. An intraperitoneal injection of a blocker of NMDA receptor channel, but not NMDA itself, led to marked potentiation of DNA binding activity of the transcription factor activator protein-1 in adrenal nuclear extracts 2 hr after administration. These results suggest that heteromeric NMDA receptor channels may be constitutively and functionally expressed with glycosylation of NR-1 subunit under the influence of tonic stimulation by circulating ...Continue Reading

References

Aug 1, 1992·Journal of the Autonomic Nervous System·R D O'SheaP M Beart
Nov 1, 1991·Trends in Pharmacological Sciences·S L Erdö
Feb 1, 1991·Neuroscience Research·Y Yoneda, K Ogita
Mar 1, 1989·Analytical Biochemistry·Y Yoneda, K Ogita
Sep 24, 1986·Brain Research·Y Yoneda, K Ogita
Jan 30, 1987·Biochemical and Biophysical Research Communications·Y Yoneda, K Ogita
Jul 1, 1986·Neuroscience Research·Y Yoneda, K Ogita
Jan 1, 1994·Annual Review of Neuroscience·M Hollmann, S Heinemann
Aug 1, 1993·Brain Research. Molecular Brain Research·H KiyamaM Tohyama
Apr 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C VillalobosJ Garcia-Sancho
Feb 22, 2001·Biochemical and Biophysical Research Communications·E HinoiY Yoneda
Mar 15, 2001·Neurochemistry International·E Hinoi, Y Yoneda
Apr 3, 2001·Trends in Pharmacological Sciences·T M Skerry, P G Genever

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Citations

Dec 13, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Melanie J Powers, Charles E Wood
Jun 19, 2007·Neurotoxicology·Mark A EdwardsJacqueline K Phillips
Oct 14, 2004·Redox Report : Communications in Free Radical Research·Frantisek St'astnýAbel Santamaría
Nov 18, 2009·European Journal of Anaesthesiology·Li-Chun HanWei Chai
Jun 26, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Eiichi HinoiYukio Yoneda
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Geeta RaiBarbara A Newman
Dec 23, 2003·European Journal of Biochemistry·Eiichi HinoiYukio Yoneda
Dec 2, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Stefanie D KrämerSimon M Ametamey

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