PMID: 7011401Jan 15, 1981Paper

Constitutive hepatic glucokinase activity in db/db and ob/ob mice

Biochimica Et Biophysica Acta
T T Yen, N B Stamm

Abstract

The specific activity of hepatic glucokinase (ATP: D-glucose 6-phosphotransferase, EC 2.7.1.2) in db/db mice and ob/ob mice was higher than in normal mice. All enzymes had a similar Km and, thus, the difference in activity was not due to differences in the affinity of enzyme molecules to substrates. Mixing liver extracts with high or low enzyme activities yielded additive results, as expected, which ruled out the involvement of an inhibitor or activator of the enzyme. Fasting normal mice of either strain for three days decreased glucokinase activity. However, fasting db/db or ob/ob mice for as long as 10 days had no effect on enzyme activity, indicating that glucokinase in db/db or ob/ob mice was out of regulation or constitutive. The constant, abnormally high glucokinase activity may be a contributing factor to the obesity of ob/or or db/db mice. These mice provide a model system to study the regulation of this rate-limiting enzyme of glucose metabolism.

References

Apr 1, 1977·Biochemical Genetics·D L Coleman
Aug 23, 1976·Biochimica Et Biophysica Acta·T T YenD V Pearson
Dec 5, 1973·Biochimica Et Biophysica Acta·O Greengard, H K Dewey
Apr 1, 1972·Archives of Biochemistry and Biophysics·S J Pilkis
Apr 1, 1967·Diabetologia·D L Coleman, K P Hummel
Sep 22, 1970·Biochimica Et Biophysica Acta·S J Pilkis
Feb 1, 1964·The Biochemical Journal·D G Walker, S Rao
Jan 1, 1964·Advances in Enzyme Regulation·C SharmaS Weinhouse
Dec 1, 1965·The Biochemical Journal·D G Walker, G Holland
Aug 1, 1961·The Biochemical Journal·G N WILKINSON
Feb 1, 1964·Archives of Biochemistry and Biophysics·M D BLUMENTHALI L CHAIKOFF
Feb 1, 1964·Archives of Biochemistry and Biophysics·M D BLUMENTHALI L CHAIKOFF

❮ Previous
Next ❯

Citations

Jun 1, 1992·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·R J Middleton, D G Walker
Nov 8, 2013·Cellular and Molecular Life Sciences : CMLS·Maaike H Oosterveer, Kristina Schoonjans
Jan 9, 2017·Biochimica Et Biophysica Acta. Molecular Cell Research·Jennifer Rieusset
Dec 6, 2008·The Journal of Veterinary Medical Science·Hisayo MorinagaMutsuyoshi Matsushita
Jul 10, 2012·The Journal of Clinical Investigation·Maaike H OosterveerKristina Schoonjans
Sep 1, 1990·The American Journal of Physiology·J T LahtelaJ Katz
Jan 1, 1984·The American Journal of Physiology·M D Meglasson, F M Matschinsky

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.