Constitutive integrin activation on tumor cells contributes to progression of leptomeningeal metastases

Neuro-oncology
Dieta BrandsmaEmile E Voest

Abstract

Leptomeningeal metastases are a serious neurological complication in cancer patients and associated with a dismal prognosis. Tumor cells that enter the subarachnoid space adhere to the leptomeninges and form tumor deposits. It is largely unknown which adhesion molecules mediate tumor cell adhesion to leptomeninges. We studied the role of integrin expression and activation in the progression of leptomeningeal metastases. For this study, we used a mouse acute lymphocytic leukemic cell line that was grown in suspension (L1210-S cell line) to develop an adherent L1210 cell line (L1210-A) by selectively culturing the few adherent cells in the cell culture. beta1, beta2, and beta3 integrins were in a constitutively high active state on L1210-A cells and in a low, but inducible, active state on L1210-S cells. Expression levels of these integrins were comparable in the two cell lines. Static adhesion levels of L1210-A cells on a leptomeningeal cell layer were significantly higher than those of L1210-S cells. All mice that were injected intrathecally with L1210-A cells died rapidly of leptomeningeal leukemia. In contrast, 45% long-term survival was seen after intrathecal injection of mice with L1210-S cells. Our data indicate that const...Continue Reading

References

Aug 1, 1988·Cell Structure and Function·T YatohgoM Hayashi
Jul 1, 1988·Current Problems in Cancer·W A Bleyer, T N Byrne
Apr 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F M BalisD G Poplack
May 1, 1984·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J FrickT Anderson
May 1, 1994·Archives of Neurology·R GrantL Junck
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·U GosslarB Holzmann
Jan 1, 1995·Annual Review of Cell and Developmental Biology·M A SchwartzM H Ginsberg
Aug 8, 1998·Journal of Neuro-oncology·L M DeAngelis
Mar 10, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·T C van der ReeM J van den Bent
Apr 28, 1999·Advances in Cancer Research·E Ruoslahti
Jun 11, 1999·Advances in Immunology·Y ShimizuM H Ginsberg
Jul 27, 1999·Journal of Neuro-oncology·J C ReijneveldE E Voest
Mar 22, 2000·The Journal of Cell Biology·K A ReedquistJ L Bos
Sep 9, 2000·Current Opinion in Cell Biology·Y van Kooyk, C G Figdor
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·B Felding-HabermannB M Mueller
Sep 18, 2002·Immunological Reviews·Klaus Ley
Nov 14, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Dieta BrandsmaEmile E Voest
Sep 29, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Shomron Ben-Horin, Ilan Bank

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Citations

Oct 23, 2012·Journal of Neurosurgery. Pediatrics·Eric M ThompsonEdward A Neuwelt
Apr 19, 2013·Cytoskeleton·Jeroen D LangereisLaurien H Ulfman
Mar 9, 2012·Advances in Hematology·Sabrina DonnouSylvain Fisson
Jun 10, 2009·Journal of Proteome Research·Jeroen D LangereisLaurien H Ulfman

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