Constitutive over expression of serine/threonine protein phosphatase 5 (PP5) augments estrogen-dependent tumor growth in mice

Cancer Letters
Teresa GoldenRichard E Honkanen

Abstract

Serine/threonine protein phosphatase 5 (PP5) appears to play an underappreciated role in the regulation of cellular proliferation. In estrogen-responsive cells, PP5 expression is stimulated by 17 beta-estradiol, and in a variety of p53 wild-type tumor cells the suppression of PP5 expression with ISIS 15534 inhibits growth. To further explore the relationship between PP5 and the development of human cancer, here we tested the effect of elevated PP5 expression on tumor growth using a mouse xenograph model and a stable MCF-7 cell line in which the expression of wild-type PP5 was placed under the control of tetracycline-off regulated transactivator and operator plasmids. In the xenograph model a modest two fold increase in PP5 protein levels significantly enhanced the growth rate of estrogen-dependent tumors, suggesting PP5 plays a positive role in tumor development.

References

Oct 1, 1986·Endocrinology·J G ScammellP S Dannies
May 14, 1999·Trends in Endocrinology and Metabolism : TEM·B Cenni, D Picard
Feb 17, 2001·Breast Cancer : the Journal of the Japanese Breast Cancer Society·S Kato
Jan 10, 2003·The Journal of Biological Chemistry·Gudrun UrbanRichard E Honkanen
Jan 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·Thomas WechslerMatthias Wabl
Feb 12, 2004·Genes & Development·Ambereen AliXiao-Fan Wang

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Citations

May 18, 2012·American Journal of Respiratory Cell and Molecular Biology·Belaid BouazzaOmar Tliba
Mar 23, 2005·Current Opinion in Cell Biology·Monica Gallego, David M Virshup
Mar 23, 2015·Cellular and Molecular Neurobiology·Xinglong ZhiGuilin Li
Feb 19, 2008·Biochimica Et Biophysica Acta·Teresa GoldenRichard E Honkanen
Oct 19, 2014·Applied Biochemistry and Biotechnology·Liang FengShibo Sun
May 10, 2008·Angewandte Chemie·Ivano BertiniEleonora Talluri
May 3, 2020·The Journal of Eukaryotic Microbiology·Yu YuHongyu Han
Feb 20, 2007·The Journal of Parasitology·Sedrick AndersonMinu Chaudhuri
Feb 13, 2016·Oncology Letters·Xiaojiao ZhengLining Cui
Jul 3, 2021·Cancers·Jean-Paul BryantYeshavanth Kumar Banasavadi-Siddegowda

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