PMID: 8966228Feb 1, 1996Paper

Constraints in the use of repair half times and mathematical modelling for the clinical application of HDR and PDR treatment schedules as an alternative for LDR brachytherapy

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
L A PopA J van der Kogel

Abstract

Using theoretical models based on radiobiological principles for the design of new treatment schedules for HDR and PDR brachytherapy, it is important to realise the impact of assumptions regarding the kinetics of repair. Extrapolations based on longer repair half times in a continuous LDR reference scheme may lead to the calculation of dangerously high doses for alternative HDR and PDR treatment schedules. We used the clinical experience obtained with conventional ERT and LDR brachytherapy in head and neck cancer as a clinical guideline to check the impact of the radiobiological parameters used. Biologically equivalent dose (BED) values for the in clinical practice of LDR brachytherapy recommended dose of 65-70 Gy (prescribed at a dose rate between 30-50 cGy/h) are calculated as a function of the repair half time. These BED values are compared with the biological effect of a clinical reference dose of conventional ERT with 2 Gy/day and complete repair between the fractions. From this comparison of LDR and ERT treatment schedules, a range of values for the repair half times of acute or late responding tissues is demarcated with a reasonable fit to the clinical data. For the acute effects (or tumor control) the best fits are obta...Continue Reading

References

Dec 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·R GuttenbergerK K Ang
Dec 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·K K AngY Feng
Dec 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J H Hendry
Feb 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G J van den Aardweg, J W Hopewell
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·J Fowler, M Mount
May 1, 1991·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J J MazeronB Pierquin
Jan 1, 1991·International Journal of Radiation Oncology, Biology, Physics·D J Brenner, E J Hall
Aug 1, 1990·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·V BenkJ P Le Bourgeois
Nov 1, 1990·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·H D ThamesW Van den Bogaert
Feb 1, 1990·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J M TaylorW M Mendenhall
Jun 1, 1990·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J F Fowler
Aug 1, 1990·International Journal of Radiation Oncology, Biology, Physics·J J MazeronB Pierquin
Dec 1, 1989·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·W M MendenhallR R Million
Apr 1, 1989·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·H D Thames
Aug 1, 1989·The British Journal of Radiology·J F Fowler
Jun 1, 1989·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·I Turesson, H D Thames
Aug 1, 1989·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·R G Dale
Aug 1, 1987·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G G SteelJ H Peacock
Jan 1, 1988·Acta Oncologica·H R WithersB Maciejewski
Feb 1, 1987·International Journal of Radiation Oncology, Biology, Physics·E L Travis, S L Tucker
Nov 1, 1982·International Journal of Radiation Oncology, Biology, Physics·G W Barendsen
Aug 1, 1983·International Journal of Radiation Oncology, Biology, Physics·C C WangP J Biggs
Jul 1, 1994·International Journal of Radiation Oncology, Biology, Physics·D J BrennerR K Sachs
Oct 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S A Roberts, J H Hendry
May 20, 1993·International Journal of Radiation Oncology, Biology, Physics·J F Fowler

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Citations

Jun 19, 2008·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A Polo
Jun 28, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·L A PopA J van der Kogel
Feb 13, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·D PeiffertJ J Mazeron
May 23, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·P SminiaD González González
Nov 19, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·K HaustermansE van der Schueren
Aug 23, 2001·International Journal of Radiation Oncology, Biology, Physics·L A PopA J van der Kogel
Feb 19, 2002·International Journal of Radiation Oncology, Biology, Physics·Peter SminiaJack F Fowler
Mar 1, 1997·International Journal of Radiation Oncology, Biology, Physics·J F Fowler, E F Van Limbergen
Oct 23, 1997·International Journal of Radiation Oncology, Biology, Physics·J F Fowler
Mar 5, 1998·International Journal of Radiation Oncology, Biology, Physics·L A PopA J van der Kogel
May 20, 1998·International Journal of Radiation Oncology, Biology, Physics·P SminiaD G González
Feb 3, 2000·International Journal of Radiation Oncology, Biology, Physics·V StrnadR Sauer
Aug 6, 1998·The British Journal of Radiology·R G Dale, B Jones
Apr 9, 2013·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·C Hennequin, J-J Mazeron
Sep 13, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Daniela Kauer-DornerWolfgang Dörr
Mar 6, 1998·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·L KeilholzR Sauer

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