Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus

The Journal of Experimental Medicine
R DraenertJ Martinez-Picado

Abstract

The predictability of virus-host interactions and disease progression in rapidly evolving human viral infections has been difficult to assess because of host and genetic viral diversity. Here we examined adaptive HIV-specific cellular and humoral immune responses and viral evolution in adult monozygotic twins simultaneously infected with the same virus. CD4 T cell counts and viral loads followed similar trajectories over three years of follow up. The initial CD8 T cell response targeted 17 epitopes, 15 of which were identical in each twin, including two immunodominant responses. By 36 months after infection, 14 of 15 initial responses were still detectable in both, whereas all new responses were subdominant and remained so. Of four responses that declined in both twins, three demonstrated mutations at the same residue. In addition, the evolving antibody responses cross-neutralized the other twin's virus, with similar changes in the pattern of evolution in the envelope gene. These results reveal considerable concordance of adaptive cellular and humoral immune responses and HIV evolution in the same genetic environment, suggesting constraints on mutational pathways to HIV immune escape.

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Citations

Dec 28, 2011·Medical Microbiology and Immunology·Thomas VollbrechtRika Draenert
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Methods Mentioned

BETA
glycosylation
ELISA
profiler
PCR
FCS
FACS
Assay

Software Mentioned

Genotyper
MEGA
Modeltest
Sequencher
PAUP
ClustalW
Graph Pad Prism

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