Constraints on intron evolution in the gene encoding the myosin alkali light chain in Drosophila.

Genetics
B G LeichtA G Clark

Abstract

Interspecific comparisons of intron sequences reveal conserved blocks of invariant nucleotides and several other departures from the strictly neutral model of molecular evolution. To distinguish the past action of evolutionary forces in introns known to have regulatory information, we examined nucleotide sequence variation at 991 sites in a random sample of 16 Drosophila melanogaster alleles of the gene encoding the myosin alkali light chain (Mlc1). The Mlc1 gene of D. melanogaster encodes two MLC1 isoforms via developmentally regulated alternative pre-mRNA splicing. Analyses of these data reveal that introns 4 and 5, which flank the alternatively spliced exon 5, have reduced levels of both intraspecific polymorphism and interspecific divergence relative to intron 3. No polymorphism was observed in any of the exons examined in D. melanogaster. A genealogical analysis clearly demonstrates the occurrence of intragenic recombination in the ancestral history of Mlc1. Recombination events are estimated to be 13 times more likely than mutation events over the span of the sequenced region. Although there is little evidence for pairwise linkage disequilibrium in the Mlc1 region, higher order disequilibrium does seem to be present in th...Continue Reading

Citations

Oct 3, 2003·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Patricia Lem, Joëlle Lallemand
Mar 2, 2006·Systematic Biology·Simon CreerRoger S Thorpe
Nov 20, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M D Purugganan
May 3, 2000·Genes & Genetic Systems·Y ChenW Stephan
Jun 3, 2008·Molecular Biology and Evolution·Penelope R HaddrillPeter Andolfatto
Sep 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ying Chen, Wolfgang Stephan
Oct 28, 2009·Journal of Molecular Evolution·Sophie Marion de ProcéBrian Charlesworth

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