Constriction of mouse hepatic venules and sinusoids by endothelins through ETB receptor subtype

International Journal of Microcirculation, Clinical and Experimental
Y ItoA Kakita

Abstract

This study was conducted to examine the effects of endothelin (ET)-1 and ET-3 on hepatic venules and sinusoids and to identify the subtypes of ET receptors. Hepatic venules and sinusoids of anesthetized mice were observed at the edge of the liver. ET-1, ET-3 and sarafotoxin (S6c, a selective ETB receptor agonist) were applied topically over the microvasculature. ET-1, ET-3 and S6c (1-100 microM, 30 microliters) induced dose-dependent vasoconstriction of the portal venules, the sinusoids and the central venules. The ETs and S6c were equipotent for these microvessels. BQ-123 (a selective ETA receptor antagonist) inhibited the constrictive effects of ET-3 (not of ET-1) on the portal venules and central venules, whereas it had no inhibitory effect on the sinusoids. In mouse hepatic venules and sinusoids, the vasoconstriction induced by ET-1 and ET-3 was mediated mainly through the ETB receptor subtype and partly through an unknown BQ-123-sensitive ET receptor subtype in the portal and central venules, and only through the ETB receptor subtype in the sinusoids.

Citations

Jan 15, 2008·Pflügers Archiv : European journal of physiology·Toshishige ShibamotoShozo Koyama
Apr 29, 2005·The Japanese Journal of Physiology·Toshishige ShibamotoYasutaka Kurata
Sep 10, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Quan JinJi-Xing Nan
Sep 24, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Takato UenoJean Rosenbaum
Nov 27, 2009·Journal of Cardiovascular Pharmacology·Zhan-Sheng ZhaoYasutaka Kurata
Mar 29, 2014·World Journal of Hepatology·Letitia Adela Maria StrebaIon Rogoveanu
May 23, 2002·Shock·Rajiv BavejaMark G Clemens
Sep 20, 2000·American Journal of Physiology. Heart and Circulatory Physiology·C F Rothe, R Maass-Moreno

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