Constructing and characterizing a bioactive small molecule and microRNA association network for Alzheimer's disease

Journal of the Royal Society, Interface
Fanlin MengWei Jiang

Abstract

Alzheimer's disease (AD) is an incurable neurodegenerative disorder. Much effort has been devoted to developing effective therapeutic agents. Recently, targeting microRNAs (miRNAs) with small molecules has become a novel therapy for human diseases. In this study, we present a systematic computational approach to construct a bioactive Small molecule and miRNA association Network in AD (SmiRN-AD), which is based on the gene expression signatures of bioactive small molecule perturbation and AD-related miRNA regulation. We also performed topological and functional analysis of the SmiRN-AD from multiple perspectives. At the significance level of p ≤ 0.01, 496 small molecule-miRNA associations, including 25 AD-related miRNAs and 275 small molecules, were recognized and used to construct the SmiRN-AD. The drugs that were connected with the same miRNA tended to share common drug targets (p = 1.72 × 10(-4)) and belong to the same therapeutic category (p = 4.22 × 10(-8)). The miRNAs that were linked to the same small molecule regulated more common miRNA targets (p = 6.07 × 10(-3)). Further analysis of the positive connections (quinostatin and miR-148b, amantadine and miR-15a) and the negative connections (melatonin and miR-30e-5p) indica...Continue Reading

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Citations

Oct 14, 2014·International Journal of Molecular Sciences·Rüdiger Hardeland
Jan 14, 2016·Scientific Reports·Fanlin MengWei Jiang
Feb 13, 2019·Briefings in Bioinformatics·Xu ZhouWei Jiang
Oct 31, 2018·Frontiers in Pharmacology·Na-Na GuanXing Chen
Mar 14, 2019·International Journal of Molecular Sciences·Rüdiger Hardeland
Apr 8, 2020·Frontiers in Bioengineering and Biotechnology·Fuxing LiuLiqian Zhou
Jan 12, 2017·International Journal of Molecular Medicine·Yuze CaoLihua Wang
Jan 18, 2019·Molecular Therapy. Nucleic Acids·Jia QuJian-Qiang Li
Mar 18, 2021·PloS One·Edgardo Galan-Vasquez, Ernesto Perez-Rueda
Jun 26, 2021·Frontiers in Cell and Developmental Biology·Hassan AminiRussel J Reiter
Mar 7, 2019·Journal of Chemical Information and Modeling·Chun-Chun WangJian-Qiang Li
Oct 2, 2021·BMC Bioinformatics·Giuseppe Agapito, Mario Cannataro

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