Constructing de novo H2O2 signaling via induced protein proximity

ACS Chemical Biology
Guihua ZengFu-Sen Liang

Abstract

A new chemical strategy has been developed to generate de novo signaling pathways that link a signaling molecule, H2O2, to different downstream cellular events in mammalian cells. This approach combines the reactivity-based H2O2 sensing with the chemically induced protein proximity technology. By chemically modifying abscisic acid with an H2O2-sensitive boronate ester probe, novel H2O2 signaling pathways can be engineered to induce transcription, protein translocation and membrane ruffle formation upon exogenous or endogenous H2O2 stimulation. This strategy has also been successfully applied to gibberellic acid, which provides the potential to build signaling networks based on orthogonal cell stimuli.

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Citations

Oct 4, 2015·Current Opinion in Chemical Biology·Stephanie VoßYao-Wen Wu
Feb 22, 2017·ACS Synthetic Biology·Guihua ZengFu-Sen Liang
Feb 8, 2020·International Journal of Molecular Sciences·Weiye ZhaoFu-Sen Liang
Feb 7, 2017·Frontiers in Molecular Neuroscience·Payel MondalKai Zhang
Apr 21, 2018·ACS Chemical Biology·Qi ZhangEvripidis Gavathiotis

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