Constructing the ecstasy of MDMA from its component mental organs: Proposing the primer/probe method

Medical Hypotheses
Thomas S Ray

Abstract

The drug MDMA, commonly known as ecstasy, produces a specific and distinct open hearted mental state, which led to the creation of a new pharmacological class, "entactogens". Extensive literature on its mechanisms of action has come to characterize MDMA as a "messy" drug with multiple mechanisms, but the consensus is that the distinctive entactogenic effects arise from the release of neurotransmitters, primarily serotonin. I propose an alternative hypothesis: The entactogenic mental state is due to the simultaneous direct activation of imidazoline-1 (I1) and serotonin-2 (5-HT2) receptors by MDMA. This hypothesis emerges from "mental organ" theory, which embodies many hypotheses, the most relevant of which are: "Mental organs" are populations of neurons that all express their defining metabotropic receptor, and each mental organ plays a distinct role in the mind, a role shaped by evolution as mental organs evolve by duplication and divergence. Mental organs are the mechanism by which evolution sculpts the mind. Mental organs can be in or out of consciousness. In order for a mental organ to enter consciousness, three things must happen: The mental organ must be activated directly at its defining receptor. 5-HT2 must be simultaneo...Continue Reading

References

Jan 1, 1990·Annals of the New York Academy of Sciences·M TeitlerR A Glennon
Feb 1, 1989·Archives of General Psychiatry·S J Peroutka
Oct 1, 1986·Journal of Psychoactive Drugs·A T Shulgin
Oct 1, 1986·Journal of Psychoactive Drugs·G Greer, R Tolbert
Apr 27, 1988·European Journal of Pharmacology·G BattagliaE B De Souza
Oct 1, 1986·Journal of Medicinal Chemistry·D E NicholsA T Shulgin
Sep 1, 1968·The American Journal of Psychiatry·S H SnyderH Weingartner
Jul 1, 1974·Archives of General Psychiatry·S H SnyderC F Barfknecht
Jan 1, 1971·Archives of General Psychiatry·S H SnyderL A Faillace
Mar 1, 1971·The Journal of Clinical Pharmacology and New Drugs·H WeingartnerL A Faillace
Jan 1, 1981·Journal of Psychoactive Drugs·A Shulgin
Mar 12, 1999·Neuroscience and Biobehavioral Reviews·K M HegadorenM Bourin
Mar 18, 1999·Drug and Alcohol Dependence·K L Jansen
Aug 24, 1999·The Journal of Clinical Psychiatry·D J Stein, J Rink
Mar 25, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M E LiechtiF X Vollenweider
Jun 29, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M E Liechti, F X Vollenweider
Sep 16, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M E LiechtiF X Vollenweider
Feb 13, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M E LiechtiF X Vollenweider
Jun 12, 2001·The International Journal on Drug Policy·D HansenT Lower
Aug 30, 2001·Health Education Research·A BoysJ Strang
Aug 23, 2002·Behavioural Brain Research·Gilberto GerraFrancesca Brambilla
Oct 31, 2002·Human Psychopharmacology·Matthias E. Liechti, Franz X. Vollenweider
Apr 2, 2003·Pharmacology & Therapeutics·J C Cole, H R Sumnall
Jul 19, 2003·Pharmacological Reviews·A Richard GreenM Isabel Colado
Oct 9, 2003·Human Psychopharmacology·Suzanne L VerheydenH Valerie Curran
Feb 6, 2004·Pharmacology & Therapeutics·David E Nichols
Feb 12, 2004·Journal of Psychopharmacology·Suzanne L VerheydenH Valerie Curran
Mar 19, 2004·Annals of the New York Academy of Sciences·A Halaris, J E Piletz
Mar 19, 2004·Annals of the New York Academy of Sciences·J E PiletzH Zhu
Jun 30, 2004·Medicinal Research Reviews·Christophe Dardonville, Isabel Rozas
Dec 8, 2004·Journal of Psychopharmacology·A C ParrottN Solowij
Jul 29, 2005·Substance Use & Misuse·Sean P BarrettRobert O Pihl
Jan 13, 2006·Journal of Psychopharmacology·Harry R SumnallLisa Jerome
Mar 15, 2006·Cardiovascular & Hematological Agents in Medicinal Chemistry·G A Head, D N Mayorov

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Citations

Mar 24, 2018·Frontiers in Pharmacology·Link R Swanson
Oct 23, 2019·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Milena Jadrijević-Mladar TakačTin Takač

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