PMID: 6164056Dec 1, 1980Paper

Construction and identification of bacterial plasmids containing nucleotide sequence for human leukocyte interferon

Proceedings of the National Academy of Sciences of the United States of America
S MaedaS Pestka

Abstract

Bacterial plasmids containing human leukocyte interferon sequences were constructed and identified. Identification was confirmed by correspondence of the nucleotide sequence with out amino acid sequence of human leukocyte interferon. The finding of bacterial recombinants containing distinct leukocyte interferon sequences is consistent with our purification of different leukocyte interferon species. We conclude that what has been designated human leukocyte interferon is, indeed, a class of homologous proteins. Preliminary indications suggest that their diversity appears to be represented by individual genomic equivalents. Each of the individual species exhibits characteristic activities. The structural modulation of these biological activities has immense significance for understanding the natural role of the interferons and for refining and developing their ultimate therapeutic potential.

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Citations

Feb 15, 2001·Biopolymers·S Pestka
Jan 1, 1993·Mammalian Genome : Official Journal of the International Mammalian Genome Society·R FriesJ E Womack
Jan 1, 1985·Pharmacology & Therapeutics·S Pestka, S J Tarnowski
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Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G M RingoldF McCormick
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