Construction and integrated analysis of crosstalking ceRNAs networks in laryngeal squamous cell carcinoma

PeerJ
Yuehui Liu, Fan Ye

Abstract

Laryngeal squamous cell carcinoma (LSCC) is one of the most common malignant tumours of the head and neck. Recent evidence has demonstrated that lncRNAs play important roles in tumour progression and could be used as biomarkers for early diagnosis, prognosis, and potential therapeutic targets. The "competitive endogenous RNA (ceRNA)" hypothesis states that lncRNAs competitively bind to miRNAs through their intramolecular miRNA reaction elements (MREs) to construct a wide range of ceRNA regulatory networks. This study aims to predict the role of ceRNA network in LSCC, for advancing the understanding of underlying mechanisms of tumorigenesis. In this study, the functions of lncRNAs as ceRNAs in LSCC and their prognostic significance were investigated via comprehensive integrated expression profiles data of lncRNAs, mRNAs, and miRNAs obtained from The Cancer Genome Atlas (TCGA). Protein-protein interaction, gene ontology, pathway, and Kaplan-Meier curves analysis were used to profile the expression and function of altered RNAs in LSCC. As a result, 889 lncRNAs, 55 miRNAs and 1946 mRNAs were found to be differentially expressed in LSCC. These altered mRNAs were mainly involved in extracellular matrix organization, calcium signaling...Continue Reading

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Citations

Dec 30, 2020·Technology in Cancer Research & Treatment·Zhibin JingZheng Liang
May 12, 2021·Disease Models & Mechanisms·Meredith Hill, Nham Tran
Jul 7, 2021·Current Pharmaceutical Design·Jinlan ChenChengfu Yuan

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Datasets Mentioned

BETA
AC108134.1

Methods Mentioned

BETA
RNA-Seq
miRNA-Seq

Software Mentioned

ClueGO
LSCC
KOBAS
CentiScape
TCGA
gplots
DAVID
String ( Search Tool for the Retrieval of Interacting Genes )
edgeR
Mircode

Related Concepts

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